Quantitative Assessment of Optic Nerve with Diffusion Tensor Imaging in Patients with Thyroid Orbitopathy

Berna Özkan, Yonca Anik, Büşra Katre, Özgül Altintaş, Mehmet Gençtürk, Nurşen Yüksel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose: To detect abnormalities of the optic nerve in patients with thyroid orbitopathy using diffusion tensor MRI. Methods: Twenty-eight patients with Graves orbitopathy prospectively underwent diffusion tensor imaging scanning. A full ophthalmic examination including visual acuity, intraocular pressure, fundoscopy, and visual field analysis was performed. Clinical activity scores were also calculated. Fractional anisotropy (FA) and mean diffusivity values of the patients were compared with age and sex-matched healthy control subjects. Results: The mean FA values were decreased and mean diffusivity values were increased significantly in patients with Graves orbitopathy compared with the control subjects (p < 0.001). There was a strong reverse correlation between the FA levels and the visual fields in 4 quadrants of the optic nerve. In addition, there was a strong correlation between the degree of proptosis and the FA values in both eyes. The mean diffusivity levels were also correlated with changes in the visual field and the degree of proptosis. Conclusion: FA and mean diffusivity levels measured with the diffusion tensor imaging of the thyroid orbitopathy patients were affected. The changes in diffusion tensor imaging were also correlated with the ophthalmologic tests of the patients.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalOphthalmic plastic and reconstructive surgery
Issue number5
StatePublished - Sep 21 2015


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