Questioning our perceptions about evolution of biodegradative enzymes

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Abstract

A century of biodegradation and natural product chemistry research has provided the backdrop for more deeply understanding the evolution of new degradative enzymes. Natural products serve as substrates and select for enzymes that may later act on industrial chemicals via analogous mechanisms. Enzymes that work on a range of substrates are said to be catalytically promiscuous. Studies are advancing with the development of tools to quantitatively assess catalytic promiscuity. Moreover, the role of catalytic promiscuity in evolution can now be studied by looking at genome-wide changes and their effects on cell survival. The expansion of public databases dealing with chemical compounds and metabolic reactions facilitates this research and now allows for the computational prediction of biodegradative metabolism.

Original languageEnglish (US)
Pages (from-to)244-251
Number of pages8
JournalCurrent Opinion in Microbiology
Volume12
Issue number3
DOIs
StatePublished - Jun 2009

Bibliographical note

Funding Information:
The support of Syngenta Crop Protection is gratefully acknowledged. Research on computational predictions has been supported by National Science Foundation grant NSF0543416. I thank Naomi Kreamer for assistance with the figures.

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