Quinidine-induced neutropenia: Report of a case with drug-dependent inhibition of granulocyte colony generation1

Joao L. Ascensao, Patrick J. Flynn, Arne Slungaard, William Wachsman, Esmail D. Zanjani, Harry S. Jacob

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We describe a case of quinidine-induced agranulocytosis in which in vitro marrow culture studies suggested immune inhibition of committed human granulocyte-macrophage progenitors (CFU-GM). Autologous, but not allogeneic, inhibition of CFU-GM was seen with 'acute' serum from the patient in the presence of quinidine but not other drugs. Cytotoxic antibodies to mature granulocytes were not found. These studies provide a novel mechanism for drug-induced neutropenia and suggest that a battery of in vitro assays of progenitor and of mature granulocyte cytotoxicity might identify offending agents in suspected drug-induced neutropenias.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalActa Haematologica
Volume72
Issue number5
DOIs
StatePublished - Jan 1 1984

Keywords

  • Granulocyte cytotoxicity
  • Granulocyte-macrophage progenitor assay
  • Neutropenia

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