Abstract
We describe a case of quinidine-induced agranulocytosis in which in vitro marrow culture studies suggested immune inhibition of committed human granulocyte-macrophage progenitors (CFU-GM). Autologous, but not allogeneic, inhibition of CFU-GM was seen with 'acute' serum from the patient in the presence of quinidine but not other drugs. Cytotoxic antibodies to mature granulocytes were not found. These studies provide a novel mechanism for drug-induced neutropenia and suggest that a battery of in vitro assays of progenitor and of mature granulocyte cytotoxicity might identify offending agents in suspected drug-induced neutropenias.
Original language | English (US) |
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Pages (from-to) | 349-354 |
Number of pages | 6 |
Journal | Acta Haematologica |
Volume | 72 |
Issue number | 5 |
DOIs | |
State | Published - 1984 |
Keywords
- Granulocyte cytotoxicity
- Granulocyte-macrophage progenitor assay
- Neutropenia