Ra3 skin test response and HLA-A2, Antigen E, and IgE: Evidence of interactions between Antigen E and HLA

N. R. Mendell; D. B. Amos; Malcolm N Blumenthal; G. J. Gleich; E. J. Yunis

doi:10.1016/0198-8859(82)90051-9

Ra3 skin test response and HLA-A2, Antigen E, and IgE: Evidence of interactions between Antigen E and HLA

N. R. Mendell, D. B. Amos, Malcolm N Blumenthal, G. J. Gleich, E. J. Yunis

Medicine - Pulmonary, Allergy, Critical

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Abstract

A positive association of Ra3 skin test responses with HLA-A2 has previously been reported to be evident in individuals with low IgE levels and to a greater extent in these individuals than those with high IgE levels. We give evidence based on an analysis of data from 133 individuals that Ra3 response is positively correlated with HLA-A2 among individuals with low Antigen E response and negatively associated with HLA-A2 among individuals with high Antigen E response. Furthermore, we have evidence that any observed interaction between Ra3, IgE, and HLA-A2 can be explained by the correlation between IgE and Antigen E response, and that it is Antigen E response which interacts in the relationship between HLA-A2 and Ra3 skin test response.

Original language	English (US)
Pages (from-to)	63-70
Number of pages	8
Journal	Human Immunology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/0198-8859(82)90051-9
State	Published - Feb 1982

Bibliographical note

Funding Information:
This research was supported in part by USPHS Grant GM10356, and NIH Grants AI 11483, 1 ROI-HL23631-02, and CA-20531-03.

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title = "Ra3 skin test response and HLA-A2, Antigen E, and IgE: Evidence of interactions between Antigen E and HLA",

abstract = "A positive association of Ra3 skin test responses with HLA-A2 has previously been reported to be evident in individuals with low IgE levels and to a greater extent in these individuals than those with high IgE levels. We give evidence based on an analysis of data from 133 individuals that Ra3 response is positively correlated with HLA-A2 among individuals with low Antigen E response and negatively associated with HLA-A2 among individuals with high Antigen E response. Furthermore, we have evidence that any observed interaction between Ra3, IgE, and HLA-A2 can be explained by the correlation between IgE and Antigen E response, and that it is Antigen E response which interacts in the relationship between HLA-A2 and Ra3 skin test response.",

author = "Mendell, {N. R.} and Amos, {D. B.} and Blumenthal, {Malcolm N} and Gleich, {G. J.} and Yunis, {E. J.}",

note = "Funding Information: This research was supported in part by USPHS Grant GM10356, and NIH Grants AI 11483, 1 ROI-HL23631-02, and CA-20531-03.",

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AU - Amos, D. B.

AU - Blumenthal, Malcolm N

AU - Gleich, G. J.

AU - Yunis, E. J.

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AB - A positive association of Ra3 skin test responses with HLA-A2 has previously been reported to be evident in individuals with low IgE levels and to a greater extent in these individuals than those with high IgE levels. We give evidence based on an analysis of data from 133 individuals that Ra3 response is positively correlated with HLA-A2 among individuals with low Antigen E response and negatively associated with HLA-A2 among individuals with high Antigen E response. Furthermore, we have evidence that any observed interaction between Ra3, IgE, and HLA-A2 can be explained by the correlation between IgE and Antigen E response, and that it is Antigen E response which interacts in the relationship between HLA-A2 and Ra3 skin test response.

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Ra3 skin test response and HLA-A2, Antigen E, and IgE: Evidence of interactions between Antigen E and HLA

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