Abstract
Objective: To compare the efficacy of three nutritional regimens in the prevention of weight loss. Design: A three-arm randomized controlled trial with primary outcome measure percent change in weight over four months. Patients: A total of 536 patients with CD4 count <200 cells/mm3 and stable weight, defined as <5% weight loss as determined by a weight measurement 3 to 6 months before randomization were recruited at fourteen administrative units in the United States, each unit consisting of multiple primary care sites. Intervention: The three arms were 500 kcal daily of caloric supplement with peptides and medium-chain triglycerides plus a multivitamin and mineral supplement, 500 kcal of a caloric supplement with whole protein and long- chain triglycerides plus a multivitamin and mineral supplement, and a multivitamin and mineral supplement only. Results: There were no significant differences among the three regimens in the percent change in weight (p = .74) and body cell mass (p = .63). On average, 65% of the recommended 500 kcal/day of caloric supplements containing peptides with medium-chain triglycerides and 82% of the 500 kcal/day of the caloric supplement containing whole protein and long-chain triglycerides were consumed. Conclusions: Caloric supplements do not promote increases in average weight or body cell mass in weight-stable, HIV-infected adults beyond that offered by a multivitamin and mineral supplement.
Original language | English (US) |
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Pages (from-to) | 253-259 |
Number of pages | 7 |
Journal | Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology |
Volume | 22 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1 1999 |
Keywords
- Body cell mass
- Caloric supplements
- HIV infection
- Long-chain triglycerides
- Medium-chain triglycerides
- Nutrition
- Weight