Randomized controlled trials 2: Analysis

Robert N. Foley

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

When analyzing the results of a trial the primary outcome variable must be kept in clear focus. In the analysis plan consideration must be given to comparing the characteristics of the subjects, taking account of differences in these characteristics, intention to treat analysis, interim analyses and stopping rules, mortality comparisons, composite outcomes, research design including run-in periods, factorial, stratified, and crossover designs, number needed to treat, power issues, multivariate modeling, and hypothesis-generating analyses.

Original languageEnglish (US)
Pages (from-to)177-190
Number of pages14
JournalMethods in Molecular Biology
Volume1281
DOIs
StatePublished - Jan 1 2015

Keywords

  • Analysis
  • Intention to treat
  • Multivariate modeling
  • Randomized controlled trials
  • Research design
  • Stopping rules

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