Abstract
The two-step: Chroman-3-ones are important intermediates for organic synthesis and medicinal chemistry. However, their syntheses require multiple steps and are not efficient. By using gold-catalyzed alkyne oxidation, this versatile heterocycle can be prepared in only two steps from readily available phenols and with mostly high efficiencies (see scheme).
Original language | English (US) |
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Pages (from-to) | 1915-1918 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 8 |
DOIs | |
State | Published - Feb 20 2012 |
Externally published | Yes |
Keywords
- carbenes
- gold
- heterocycles
- homogeneous catalysis
- oxidation