Dynamic computed tomography (CT) scanning of the brain was performed in 26 patients with primary degenerative dementia (PDD) and in 15 age-matched controls without evidence of a dementing illness. Changes in CT density values over time were obtained for 16 regions of interest (ROIs) that were carefully chosen to avoid overlap with adjacent cerebrospinal fluid (CSF), sulsi, or bone. CT density washout curves were compared between patients and controls to detect regions where blood brain barrier (BBB) permeability might be increased. although the patient's washout curves declined more gradually than control curves in 11 of the 14 ROIs with a functioning BBB, in no case did the difference reach statistical significance. Intrarater correlation coefficients indicated good overall reliability in the selection of ROIs.
Bibliographical noteFunding Information:
From the Geriatric Research, Education, and Clinical Center and Department of Radiology, Minneapol;.s VA Medical Center, Minneapolis, MN. Supported by Grant IPOI-AG 05309-01 from the National Institute on Aging (NIA) to M.D. Address reprint requests to Maurice W. Dysken, M.D., GRECC Program (IlG), Minneapolis VA Medical Center, One Veterans Drive, Minneapolis, MN 55417. Received September 30, 1989; revised February 12, 1990.