Rapid dynamic CT scanning to distinguish schizophrenic from normal subjects

Maurice Dysken, Clifford S. Patlak, Glen D. Dobben, Karen D. Pettigrew, John J. Bartko, Elizabeth M. Burns, John Davis, Darrel A. Regier

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Rapid dynamic computerized axial tomography (CT) density-time curves were used to detect abnormal brain regions in groups of controls and DSM-III diagnosed schizophrenics. Density-time curves were designated as plateau curves if, following a bolus injection of contrast material, they exhibited a plateau from the peak value rather than a decrease. Five of the 10 schizophrenics versus none of the 11 controls were found to possess two or more plateau curves. The psysiological basis for the plateau curves is not known, but an increase in blood-brain-barrier permeability could be involved.

Original languageEnglish (US)
Pages (from-to)165-175
Number of pages11
JournalPsychiatry Research
Issue number2
StatePublished - Feb 1987


  • Schizophrenia
  • dynamic computed tomography
  • plateau regions


Dive into the research topics of 'Rapid dynamic CT scanning to distinguish schizophrenic from normal subjects'. Together they form a unique fingerprint.

Cite this