Rapid entry into the cryptophycin core via an acyl-β-lactam macrolactonization: Total synthesis of cryptophycin-24

MariJean Eggen, Sajiv K. Nair, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

(formula presented) An efficient, concise approach to the macrolide core of the cryptophycins, potent antimitotic agents, has been achieved. The reaction sequence features a novel macrolactonization utilizing a reactive acyl-β-lactam intermediate that incorporates the β-amino acid moiety within the 16-membered macrolide core. This highly modular approach, which allows for multiple alterations throughout the structure, was successfully applied to the total synthesis of cryptophycin-24.

Original languageEnglish (US)
Pages (from-to)1813-1815
Number of pages3
JournalOrganic Letters
Volume3
Issue number12
DOIs
StatePublished - Jun 14 2001

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