Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity

Medicine & Life Sciences

• compstatin 100%
• Macroglobulins 69%
• Complement C3 65%
• Loss of Function Mutation 59%
• Alternative Pathway Complement C3 Convertase 46%
• Complement C3-C5 Convertases 40%
• Complement Inactivating Agents 38%
• Alternative Complement Pathway 35%
• Gain of Function Mutation 34%
• Mutation 29%
• Point Mutation 25%
• Blood Proteins 23%
• Psychological Inhibition 21%
• Molecular Biology 21%
• Binding Sites 20%
• Therapeutics 4%