Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Malgorzata Kamocka; Morris Pollard; Mark Suckow; Wojciech P. Mielicki; Elliot D. Rosen

Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Malgorzata Kamocka, Morris Pollard, Mark Suckow, Wojciech P. Mielicki, Elliot D. Rosen

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Abstract

Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.

Original language	English (US)
Pages (from-to)	282-286
Number of pages	5
Journal	Comparative medicine
Volume	58
Issue number	3
State	Published - Jun 2008

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abstract = "Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.",

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T1 - Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

AU - Kamocka, Malgorzata

AU - Pollard, Morris

AU - Suckow, Mark

AU - Mielicki, Wojciech P.

AU - Rosen, Elliot D.

PY - 2008/6

Y1 - 2008/6

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AB - Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.

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JO - Comparative medicine

JF - Comparative medicine

IS - 3

ER -

Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Abstract

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