Rate of cognitive decline in Alzheimer's disease is associated with EEG alpha power

Michael A. Kuskowski; James A. Mortimer; Gerald K. Morley; Stephen M. Malone; Amy J. Okaya

doi:10.1016/0006-3223(93)90108-P

Rate of cognitive decline in Alzheimer's disease is associated with EEG alpha power

Michael A. Kuskowski, James A. Mortimer, Gerald K. Morley, Stephen M. Malone, Amy J. Okaya

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Fifteen patients with Alzheimer's disease who were initially mildly or moderately impaired were followed for up to 4 years. Scores of the Mini-Mental State Examination (MMSE) were regressed on time of examination (measured at 6-month intervals) to estimate cognitive progression rates in individual patients. A quantitative electroencephalographic (EEG) examination was administered to each patient. Log-absolute EEG power in the alpha bandwidth (8-12 Hz) was found to be correlated with the computed rate of MMSE decline. This association was present for electrode sites across all regions of the scalp and remained significant when the effects of current cognitive severity were partialled out. These data suggest that a quantitative EEG measure (absolute alpha power) is related to the rate of cognitive decline in patients with Alzheimer's disease.

Original language	English (US)
Pages (from-to)	659-662
Number of pages	4
Journal	Biological psychiatry
Volume	33
Issue number	8-9
DOIs	https://doi.org/10.1016/0006-3223(93)90108-P
State	Published - 1993
Externally published	Yes

Keywords

Alzheimer's disease
MMSE
cognitive impairment
quantitative EEG

Access

10.1016/0006-3223(93)90108-P

OpenUrl availability

Full text

Cite this

@article{7665eed2d85e4d998e69202eaec5f21d,

title = "Rate of cognitive decline in Alzheimer's disease is associated with EEG alpha power",

abstract = "Fifteen patients with Alzheimer's disease who were initially mildly or moderately impaired were followed for up to 4 years. Scores of the Mini-Mental State Examination (MMSE) were regressed on time of examination (measured at 6-month intervals) to estimate cognitive progression rates in individual patients. A quantitative electroencephalographic (EEG) examination was administered to each patient. Log-absolute EEG power in the alpha bandwidth (8-12 Hz) was found to be correlated with the computed rate of MMSE decline. This association was present for electrode sites across all regions of the scalp and remained significant when the effects of current cognitive severity were partialled out. These data suggest that a quantitative EEG measure (absolute alpha power) is related to the rate of cognitive decline in patients with Alzheimer's disease.",

keywords = "Alzheimer's disease, MMSE, cognitive impairment, quantitative EEG",

author = "Kuskowski, {Michael A.} and Mortimer, {James A.} and Morley, {Gerald K.} and Malone, {Stephen M.} and Okaya, {Amy J.}",

year = "1993",

doi = "10.1016/0006-3223(93)90108-P",

language = "English (US)",

volume = "33",

pages = "659--662",

journal = "Biological psychiatry",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "8-9",

}

TY - JOUR

T1 - Rate of cognitive decline in Alzheimer's disease is associated with EEG alpha power

AU - Kuskowski, Michael A.

AU - Mortimer, James A.

AU - Morley, Gerald K.

AU - Malone, Stephen M.

AU - Okaya, Amy J.

PY - 1993

Y1 - 1993

N2 - Fifteen patients with Alzheimer's disease who were initially mildly or moderately impaired were followed for up to 4 years. Scores of the Mini-Mental State Examination (MMSE) were regressed on time of examination (measured at 6-month intervals) to estimate cognitive progression rates in individual patients. A quantitative electroencephalographic (EEG) examination was administered to each patient. Log-absolute EEG power in the alpha bandwidth (8-12 Hz) was found to be correlated with the computed rate of MMSE decline. This association was present for electrode sites across all regions of the scalp and remained significant when the effects of current cognitive severity were partialled out. These data suggest that a quantitative EEG measure (absolute alpha power) is related to the rate of cognitive decline in patients with Alzheimer's disease.

AB - Fifteen patients with Alzheimer's disease who were initially mildly or moderately impaired were followed for up to 4 years. Scores of the Mini-Mental State Examination (MMSE) were regressed on time of examination (measured at 6-month intervals) to estimate cognitive progression rates in individual patients. A quantitative electroencephalographic (EEG) examination was administered to each patient. Log-absolute EEG power in the alpha bandwidth (8-12 Hz) was found to be correlated with the computed rate of MMSE decline. This association was present for electrode sites across all regions of the scalp and remained significant when the effects of current cognitive severity were partialled out. These data suggest that a quantitative EEG measure (absolute alpha power) is related to the rate of cognitive decline in patients with Alzheimer's disease.

KW - Alzheimer's disease

KW - MMSE

KW - cognitive impairment

KW - quantitative EEG

UR - http://www.scopus.com/inward/record.url?scp=0027217334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027217334&partnerID=8YFLogxK

U2 - 10.1016/0006-3223(93)90108-P

DO - 10.1016/0006-3223(93)90108-P

M3 - Article

C2 - 8329497

AN - SCOPUS:0027217334

SN - 0006-3223

VL - 33

SP - 659

EP - 662

JO - Biological psychiatry

JF - Biological psychiatry

IS - 8-9

ER -

Rate of cognitive decline in Alzheimer's disease is associated with EEG alpha power

Abstract

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this