Rationally-designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

Ravindranadh V. Somu; Helena Boshoff; Chunhua Qiao; Eric M. Bennett; Clifton E. Barry; Courtney C. Aldrich

doi:10.1021/jm051060o

Rationally-designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

Ravindranadh V. Somu, Helena Boshoff, Chunhua Qiao, Eric M. Bennett, Clifton E. Barry, Courtney C. Aldrich

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC₉₉ = 0.19 μM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	Journal of medicinal chemistry
Volume	49
Issue number	1
DOIs	https://doi.org/10.1021/jm051060o
State	Published - Jan 12 2006

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title = "Rationally-designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis",

abstract = "A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC99 = 0.19 μM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.",

author = "Somu, {Ravindranadh V.} and Helena Boshoff and Chunhua Qiao and Bennett, {Eric M.} and Barry, {Clifton E.} and Aldrich, {Courtney C.}",

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AU - Barry, Clifton E.

AU - Aldrich, Courtney C.

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