Rationally-designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

Ravindranadh V. Somu, Helena Boshoff, Chunhua Qiao, Eric M. Bennett, Clifton E. Barry, Courtney C. Aldrich

Research output: Contribution to journalArticlepeer-review

204 Scopus citations

Abstract

A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC99 = 0.19 μM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalJournal of medicinal chemistry
Volume49
Issue number1
DOIs
StatePublished - Jan 12 2006

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