RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)

Narendra K. Tripathy, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction.

Original languageEnglish (US)
Pages (from-to)5309-5311
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number27
DOIs
StatePublished - Jun 28 2004

Bibliographical note

Funding Information:
We thank the National Institutes of Health (NCI) for financial support (CA 70369).

Keywords

  • Antitumor agents
  • Cryptophycins
  • RCM
  • Total synthesis

Fingerprint

Dive into the research topics of 'RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)'. Together they form a unique fingerprint.

Cite this