An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction.
Bibliographical noteFunding Information:
We thank the National Institutes of Health (NCI) for financial support (CA 70369).
- Antitumor agents
- Total synthesis