RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)

Narendra K. Tripathy; Gunda I. Georg

doi:10.1016/j.tetlet.2004.04.164

RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)

Narendra K. Tripathy, Gunda I. Georg

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction.

Original language	English (US)
Pages (from-to)	5309-5311
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	27
DOIs	https://doi.org/10.1016/j.tetlet.2004.04.164
State	Published - Jun 28 2004

Bibliographical note

Funding Information:
We thank the National Institutes of Health (NCI) for financial support (CA 70369).

Keywords

Antitumor agents
Cryptophycins
RCM
Total synthesis

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title = "RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)",

abstract = "An efficient total synthesis of cryptophycin-24 (arenastatin A) is reported, which features two novel synthetic strategies, the use of a RCM reaction to form the macrocycle, and the introduction of the styrene epoxide moiety prior to the macrocyclization reaction.",

keywords = "Antitumor agents, Cryptophycins, RCM, Total synthesis",

author = "Tripathy, {Narendra K.} and Georg, {Gunda I.}",

note = "Funding Information: We thank the National Institutes of Health (NCI) for financial support (CA 70369). ",

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AU - Tripathy, Narendra K.

AU - Georg, Gunda I.

N1 - Funding Information: We thank the National Institutes of Health (NCI) for financial support (CA 70369).

PY - 2004/6/28

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KW - Cryptophycins

KW - RCM

KW - Total synthesis

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RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A)

Abstract

Bibliographical note

Keywords

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