TY - JOUR
T1 - Reaction of α-halogen substituted β-ethoxyvinyl trifluoromethyl ketones with 2-aminopyridine
T2 - New route to trifluoroacetyl-containing heterocycles
AU - Kacharova, Liliya M.
AU - Gerus, Igor I.
AU - Kacharov, Alexey D.
PY - 2002/10/28
Y1 - 2002/10/28
N2 - The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.
AB - The reaction of α-halosubstituted β-ethoxyvinyl trifluomethyl ketones with 2-aminopyridine gives 3-trifluoroacetyl imidazo [1,2-a]pyridine and 3-halo-1,1,1,-trifluoro-4-(2-pyridinylamino)-3-buten-2-ones. The product ratio depends on the nature of the α-halogen atom and the solvent.
KW - Amination
KW - Bicyclic heterocyclic compounds
KW - Cyclization
KW - Enones
KW - Fluorinated α-enamino ketones
UR - http://www.scopus.com/inward/record.url?scp=0037190662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037190662&partnerID=8YFLogxK
U2 - 10.1016/S0022-1139(02)00190-2
DO - 10.1016/S0022-1139(02)00190-2
M3 - Article
AN - SCOPUS:0037190662
SN - 0022-1139
VL - 117
SP - 193
EP - 197
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
IS - 2
ER -