Realizing the Principles for Remote and Selective Detection of Cancer Cells Using Magnetic Nanowires

Mohammad Reza Zamani Kouhpanji, Zohreh Nemati, Jaime Modiano, Rhonda Franklin, Bethanie Stadler

Research output: Contribution to journalArticlepeer-review

Abstract

The unmet demand for selective and remote detection of biological entities has urged nanobiotechnology to prioritize the innovation of biolabels that can be remotely detected. Magnetic nanowires (MNWs) have been deemed promising for remote detection as the magnetic fields can deeply and safely penetrate into tissue. However, the overlapping nature of the magnetic signatures has been a long-standing challenge for selective detection, which we resolve here. To do so, 13 types of MNWs with unique irreversible switching field (ISF) signatures were synthesized for labeling canine osteosarcoma (OSCA-8) cancer cells (one set) and polycarbonate biopolymers (12 sets). After characterizing the ISF signature of each MNW type, the MNW-labeled cancer cells were transferred onto MNW-labeled biopolymers to determine the most distinguishable ISF signatures and to discern the principles for reliable selective detection of biological entities. We show that tailoring the ISF of MNWs by tuning their coercivity is a highly effective approach for generating distinct magnetic biolabels for selective detection of cells. These findings smooth the path for the progression of nanobiotechnology by enabling the remote and selective detection of biological entities using MNWs.

Original languageEnglish (US)
Pages (from-to)7742-7749
Number of pages8
JournalJournal of Physical Chemistry B
Volume125
Issue number28
DOIs
StatePublished - Jul 22 2021

Bibliographical note

Funding Information:
This work is supported primarily by the National Science Foundation under grant no. CMMI-1762884. This work is also supported by the MN Futures Program of the University of Minnesota, the Skippy Frank Fund for Life Sciences and Translational Research, the Morris Animal Foundation Grant D15CA-047, and the Animal Cancer Care and Research Program of the University of Minnesota. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS-1542202. Part of this work was performed at the Institute for Rock Magnetism (IRM) at the University of Minnesota. The IRM is a US National Multi-user Facility supported by the Instrumentation and Facilities Program of the National Science Foundation, Earth Sciences Division (NSF/EAR 1642268) and by funding from the University of Minnesota. Parts of this work were also carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program.

Publisher Copyright:
©

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

Fingerprint

Dive into the research topics of 'Realizing the Principles for Remote and Selective Detection of Cancer Cells Using Magnetic Nanowires'. Together they form a unique fingerprint.

Cite this