TY - JOUR
T1 - Recent Advances in Understanding the Pathogenesis of Lawsonia intracellularis Infections
AU - Vannucci, F. A.
AU - Gebhart, C. J.
PY - 2014/3
Y1 - 2014/3
N2 - Proliferative enteropathy is an infectious disease caused by an obligate intracellular bacterium, Lawsonia intracellularis, and characterized by thickening of the intestinal epithelium due to enterocyte proliferation. The disease is endemic in swine herds and has been occasionally reported in various other species. Furthermore, outbreaks among foals began to be reported on breeding farms worldwide within the past 5 years. Cell proliferation is directly associated with bacterial infection and replication in the intestinal epithelium. As a result, mild to severe diarrhea is the major clinical sign described in infected animals. The dynamics of L. intracellularis infection in vitro and in vivo have been well characterized, but little is known about the genetic basis for the pathogenesis or ecology of this organism. The present review focuses on the recent advances regarding the pathogenesis and host-pathogen interaction of L. intracellularis infections.
AB - Proliferative enteropathy is an infectious disease caused by an obligate intracellular bacterium, Lawsonia intracellularis, and characterized by thickening of the intestinal epithelium due to enterocyte proliferation. The disease is endemic in swine herds and has been occasionally reported in various other species. Furthermore, outbreaks among foals began to be reported on breeding farms worldwide within the past 5 years. Cell proliferation is directly associated with bacterial infection and replication in the intestinal epithelium. As a result, mild to severe diarrhea is the major clinical sign described in infected animals. The dynamics of L. intracellularis infection in vitro and in vivo have been well characterized, but little is known about the genetic basis for the pathogenesis or ecology of this organism. The present review focuses on the recent advances regarding the pathogenesis and host-pathogen interaction of L. intracellularis infections.
KW - Lawsonia intracellularis
KW - equine proliferative enteropathy (EPE)
KW - horses
KW - obligate intracellular bacterium
KW - pathogenesis
KW - pigs
KW - porcine proliferative enteropathy (PPE)
KW - proliferative enteropathy
UR - http://www.scopus.com/inward/record.url?scp=84894568979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894568979&partnerID=8YFLogxK
U2 - 10.1177/0300985813520249
DO - 10.1177/0300985813520249
M3 - Article
C2 - 24476941
AN - SCOPUS:84894568979
SN - 0300-9858
VL - 51
SP - 465
EP - 477
JO - Veterinary pathology
JF - Veterinary pathology
IS - 2
ER -