Recent results and new hardware developments for protein crystal growth in microgravity

L. J. DeLucas; M. M. Long; K. M. Moore; W. M. Rosenblum; T. L. Bray; C. Smith; M. Carson; S. V.L. Narayana; M. D. Harrington; D. Carter; A. D. Clark; R. G. Nanni; J. Ding; A. Jacobo-Molina; G. Kamer; S. H. Hughes; E. Arnold; H. M. Einspahr; L. L. Clancy; G. S.J. Rao; P. F. Cook; B. G. Harris; S. H. Munson; B. C. Finzel; A. McPherson; P. C. Weber; F. A. Lewandowski; T. L. Nagabhushan; P. P. Trotta; P. Reichert; M. A. Navia; K. P. Wilson; J. A. Thomson; R. N. Richards; K. D. Bowersox; C. J. Meade; E. S. Baker; S. P. Bishop; B. J. Dunbar; E. Trinh; J. Prahl; A. Sacco; C. E. Bugg

doi:10.1016/0022-0248(94)90740-4

Recent results and new hardware developments for protein crystal growth in microgravity

L. J. DeLucas, M. M. Long, K. M. Moore, W. M. Rosenblum, T. L. Bray, C. Smith, M. Carson, S. V.L. Narayana, M. D. Harrington, D. Carter, A. D. Clark, R. G. Nanni, J. Ding, A. Jacobo-Molina, G. Kamer, S. H. Hughes, E. Arnold, H. M. Einspahr, L. L. Clancy, G. S.J. RaoP. F. Cook, B. G. Harris, S. H. Munson, B. C. Finzel, A. McPherson, P. C. Weber, F. A. Lewandowski, T. L. Nagabhushan, P. P. Trotta, P. Reichert, M. A. Navia, K. P. Wilson, J. A. Thomson, R. N. Richards, K. D. Bowersox, C. J. Meade, E. S. Baker, S. P. Bishop, B. J. Dunbar, E. Trinh, J. Prahl, A. Sacco, C. E. Bugg

Medicinal Chemistry

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64 Scopus citations

Abstract

Protein crystal growth experiments have been performed on 16 space shuttle missions since April 1985. The initial experiments used vapor diffusion crystallization techniques similar to those used in laboratories for earth-based experiments. More recent experiments have assessed temperature-induced crystallization as an alternative method for growing high quality protein crystals in microgravity. Results from both vapor-diffusion and temperature-induced crystallization experiments indicate that protein crystals grown in microgravity may be larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions than the best crystals of these proteins grown on earth.

Original language	English (US)
Pages (from-to)	183-195
Number of pages	13
Journal	Journal of Crystal Growth
Volume	135
Issue number	1-2
DOIs	https://doi.org/10.1016/0022-0248(94)90740-4
State	Published - Jan 1994

Bibliographical note

Funding Information:
This research was supported by NASA Con tract NAS8-36611 and NASA Grant NAGW-813. We would like to thank the engineers and technicians from the University of Alabama at Birmingham, Marshall Space Flight Center and Space Industries, Inc., and the space shuttle crews for their valuable participation in this project.

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DeLucas, L. J., Long, M. M., Moore, K. M., Rosenblum, W. M., Bray, T. L., Smith, C., Carson, M., Narayana, S. V. L., Harrington, M. D., Carter, D., Clark, A. D., Nanni, R. G., Ding, J., Jacobo-Molina, A., Kamer, G., Hughes, S. H., Arnold, E., Einspahr, H. M., Clancy, L. L., ... Bugg, C. E. (1994). Recent results and new hardware developments for protein crystal growth in microgravity. Journal of Crystal Growth, 135(1-2), 183-195. https://doi.org/10.1016/0022-0248(94)90740-4

DeLucas, LJ, Long, MM, Moore, KM, Rosenblum, WM, Bray, TL, Smith, C, Carson, M, Narayana, SVL, Harrington, MD, Carter, D, Clark, AD, Nanni, RG, Ding, J, Jacobo-Molina, A, Kamer, G, Hughes, SH, Arnold, E, Einspahr, HM, Clancy, LL, Rao, GSJ, Cook, PF, Harris, BG, Munson, SH, Finzel, BC, McPherson, A, Weber, PC, Lewandowski, FA, Nagabhushan, TL, Trotta, PP, Reichert, P, Navia, MA, Wilson, KP, Thomson, JA, Richards, RN, Bowersox, KD, Meade, CJ, Baker, ES, Bishop, SP, Dunbar, BJ, Trinh, E, Prahl, J, Sacco, A & Bugg, CE 1994, 'Recent results and new hardware developments for protein crystal growth in microgravity', Journal of Crystal Growth, vol. 135, no. 1-2, pp. 183-195. https://doi.org/10.1016/0022-0248(94)90740-4

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abstract = "Protein crystal growth experiments have been performed on 16 space shuttle missions since April 1985. The initial experiments used vapor diffusion crystallization techniques similar to those used in laboratories for earth-based experiments. More recent experiments have assessed temperature-induced crystallization as an alternative method for growing high quality protein crystals in microgravity. Results from both vapor-diffusion and temperature-induced crystallization experiments indicate that protein crystals grown in microgravity may be larger, display more uniform morphologies, and yield diffraction data to significantly higher resolutions than the best crystals of these proteins grown on earth.",

author = "DeLucas, {L. J.} and Long, {M. M.} and Moore, {K. M.} and Rosenblum, {W. M.} and Bray, {T. L.} and C. Smith and M. Carson and Narayana, {S. V.L.} and Harrington, {M. D.} and D. Carter and Clark, {A. D.} and Nanni, {R. G.} and J. Ding and A. Jacobo-Molina and G. Kamer and Hughes, {S. H.} and E. Arnold and Einspahr, {H. M.} and Clancy, {L. L.} and Rao, {G. S.J.} and Cook, {P. F.} and Harris, {B. G.} and Munson, {S. H.} and Finzel, {B. C.} and A. McPherson and Weber, {P. C.} and Lewandowski, {F. A.} and Nagabhushan, {T. L.} and Trotta, {P. P.} and P. Reichert and Navia, {M. A.} and Wilson, {K. P.} and Thomson, {J. A.} and Richards, {R. N.} and Bowersox, {K. D.} and Meade, {C. J.} and Baker, {E. S.} and Bishop, {S. P.} and Dunbar, {B. J.} and E. Trinh and J. Prahl and A. Sacco and Bugg, {C. E.}",

note = "Funding Information: This research was supported by NASA Con tract NAS8-36611 and NASA Grant NAGW-813. We would like to thank the engineers and technicians from the University of Alabama at Birmingham, Marshall Space Flight Center and Space Industries, Inc., and the space shuttle crews for their valuable participation in this project.",

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AU - Moore, K. M.

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AU - Bray, T. L.

AU - Smith, C.

AU - Carson, M.

AU - Narayana, S. V.L.

AU - Harrington, M. D.

AU - Carter, D.

AU - Clark, A. D.

AU - Nanni, R. G.

AU - Ding, J.

AU - Jacobo-Molina, A.

AU - Kamer, G.

AU - Hughes, S. H.

AU - Arnold, E.

AU - Einspahr, H. M.

AU - Clancy, L. L.

AU - Rao, G. S.J.

AU - Cook, P. F.

AU - Harris, B. G.

AU - Munson, S. H.

AU - Finzel, B. C.

AU - McPherson, A.

AU - Weber, P. C.

AU - Lewandowski, F. A.

AU - Nagabhushan, T. L.

AU - Trotta, P. P.

AU - Reichert, P.

AU - Navia, M. A.

AU - Wilson, K. P.

AU - Thomson, J. A.

AU - Richards, R. N.

AU - Bowersox, K. D.

AU - Meade, C. J.

AU - Baker, E. S.

AU - Bishop, S. P.

AU - Dunbar, B. J.

AU - Trinh, E.

AU - Prahl, J.

AU - Sacco, A.

AU - Bugg, C. E.

N1 - Funding Information: This research was supported by NASA Con tract NAS8-36611 and NASA Grant NAGW-813. We would like to thank the engineers and technicians from the University of Alabama at Birmingham, Marshall Space Flight Center and Space Industries, Inc., and the space shuttle crews for their valuable participation in this project.

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Recent results and new hardware developments for protein crystal growth in microgravity

Abstract

Bibliographical note

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