Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States

Li Mei Chen, Pierre Rivailler, Jaber Hossain, Paul Carney, Amanda Balish, Ijeoma Perry, C. Todd Davis, Rebecca Garten, Bo Shu, Xiyan Xu, Alexander Klimov, James C. Paulson, Nancy J. Cox, Sabrina Swenson, James Stevens, Amy Vincent, Marie Gramer, Ruben O. Donis

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

The evolution of classical swine influenza viruses receptor specificity preceding the emergence of the 2009 H1N1 pandemic virus was analyzed in glycan microarrays. Classical swine influenza viruses from the α, β, and γ antigenic clusters isolated between 1945 and 2009 revealed a binding profile very similar to that of 2009 pandemic H1N1 viruses, with selectivity for α2-6-linked sialosides and very limited binding to α2-3 sialosides. Despite considerable genetic divergence, the 'human-like' H1N1 viruses circulating in swine retained strong binding preference for α2-6 sialylated glycans. Interspecies transmission of H1N1 influenza viruses from swine to humans or from humans to swine has not driven selection of viruses with distinct novel receptor binding specificities. Classical swine and human seasonal H1N1 influenza viruses have conserved specificity for similar α2-6-sialoside receptors in spite of long term circulation in separate hosts, suggesting that humans and swine impose analogous selection pressures on the evolution of receptor binding function.

Original languageEnglish (US)
Pages (from-to)401-410
Number of pages10
JournalVirology
Volume412
Issue number2
DOIs
StatePublished - Apr 10 2011

Bibliographical note

Funding Information:
Glycan microarrays were produced for the Centers for Disease Control using the glycan library of CFG developed under funding by the National Institute of General Medical Sciences , Grant GM62116 . The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the Agency for Toxic Substances and Disease Registry.

Keywords

  • Binding
  • H1 hemagglutinin
  • Human
  • Influenza
  • Receptor
  • Sialic acid
  • Swine

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