Receptor usage and cell entry of porcine epidemic diarrhea coronavirus

Chang Liu, Jian Tang, Yuanmei Ma, Xueya Liang, Yang Yang, Guiqing Peng, Qianqian Qi, Shibo Jiang, Jianrong Li, Lanying Du, Fang Li

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.

Original languageEnglish (US)
Pages (from-to)6121-6125
Number of pages5
JournalJournal of virology
Volume89
Issue number11
DOIs
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015, American Society for Microbiology.

Fingerprint Dive into the research topics of 'Receptor usage and cell entry of porcine epidemic diarrhea coronavirus'. Together they form a unique fingerprint.

Cite this