Reduced influence of perceptual context in schizophrenia: Behavioral and neurophysiological evidence

Victor J. Pokorny, Timothy J. Lano, Michael Paul Schallmo, Cheryl A. Olman, Scott R. Sponheim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background Accurate perception of visual contours is essential for seeing and differentiating objects in the environment. Both the ability to detect visual contours and the influence of perceptual context created by surrounding stimuli are diminished in people with schizophrenia (SCZ). The central aim of the present study was to better understand the biological underpinnings of impaired contour integration and weakened effects of perceptual context. Additionally, we sought to determine whether visual perceptual abnormalities reflect genetic factors in SCZ and are present in other severe mental disorders. Methods We examined behavioral data and event-related potentials (ERPs) collected during the perception of simple linear contours embedded in similar background stimuli in 27 patients with SCZ, 23 patients with bipolar disorder (BP), 23 first-degree relatives of SCZ, and 37 controls. Results SCZ exhibited impaired visual contour detection while BP exhibited intermediate performance. The orientation of neighboring stimuli (i.e. flankers) relative to the contour modulated perception across all groups, but SCZ exhibited weakened suppression by the perceptual context created by flankers. Late visual (occipital P2) and cognitive (centroparietal P3) neural responses showed group differences and flanker orientation effects, unlike earlier ERPs (occipital P1 and N1). Moreover, behavioral effects of flanker context on contour perception were correlated with modulation in P2 & P3 amplitudes. Conclusion In addition to replicating and extending findings of abnormal contour integration and visual context modulation in SCZ, we provide novel evidence that the abnormal use of perceptual context is associated with higher-order sensory and cognitive processes.

Original languageEnglish (US)
Pages (from-to)786-794
Number of pages9
JournalPsychological medicine
Volume51
Issue number5
DOIs
StatePublished - Apr 2021

Bibliographical note

Funding Information:
This work was supported by a Merit Review Award (#01CX000227 to SRS) from the United States Department of VA Clinical Sciences Research and Development Program and by the National Institute of Mental Health of the National Institutes of Health under Award Numbers R24MH069675 and R01MH112583 to SRS.

Publisher Copyright:
© 2019 Cambridge University Press.

Keywords

  • Context
  • EEG
  • contour
  • perception
  • psychosis
  • schizophrenia

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

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