Reducing Overuse of Proton Pump Inhibitors for Stress Ulcer Prophylaxis and Nonvariceal Gastrointestinal Bleeding in the Hospital: A Narrative Review and Implementation Guide

Karen Clarke, Nicole Adler, Deepak Agrawal, Dimpal Bhakta, Suchita Shah Sata, Sarguni Singh, Arjun Gupta, Amit Pahwa, Emily Pherson, Alexander Sun, Frank Volpicelli, Aditya Sreenivasan, Hyung J. Cho

Research output: Contribution to journalReview articlepeer-review

Abstract

Proton pump inhibitors (PPIs) are among the most commonly used medications in the world; however, these drugs carry the risk of patient harm, including acute and chronic kidney disease, Clostridium difficile infection, hypomagnesemia, and fractures. In the hospital setting, PPIs are overused for stress ulcer prophylaxis and gastrointestinal bleeding, and PPI use often continues after discharge. Numerous multifaceted interventions have demonstrated safe and effective reduction of PPI use in the inpatient setting. This narrative review and the resulting implementation guide summarize published interventions to reduce inappropriate PPI use and provide a strategy for quality improvement teams.

Original languageEnglish (US)
Pages (from-to)417-423
Number of pages7
JournalJournal of hospital medicine
Volume16
Issue number7
DOIs
StatePublished - Jul 1 2021
Externally publishedYes

PubMed: MeSH publication types

  • Journal Article
  • Review

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