Refractory pancytopenia and megaloblastic anemia due to falciparum malaria

Varun Aggarwal, Anu Maheshwari, Bimbadhar Rath, Praveen Kumar, Srikanta Basu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Anemia is a common complication in malarial infection. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anemia in malaria. We present a case with refractory megaloblastic anemia with asymptomatic falciparum malaria. We hypothesize that promoter variants in the inducible nitric oxide synthase gene might be the cause of severe refractory megaloblastic anemia and pancytopenia in our patient. Malaria should always be kept in mind as a cause of anemia especially in endemic areas even if the child is asymptomatic or there is no demonstrable parasite on routine smear examination.

Original languageEnglish (US)
Pages (from-to)283-285
Number of pages3
JournalJournal of tropical pediatrics
Issue number4
StatePublished - Aug 2011
Externally publishedYes


  • Malaria
  • Megaloblastic anemia
  • Nitric oxide
  • Pancytopenia

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