Fusarium head blight (FHB) is a serious disease of wheat (Triticum aestivum L.) worldwide that has elicited a widespread resistance-breeding effort. One approach to breeding relies on deployment of exotic quantitative trait loci (QTL) from wheat outside North America. Germplasm line KY06C-11-3-10 (Reg. No. GP-965, PI 669817) is a soft red winter wheat that is a product of an accelerated backcrossing program performed jointly by the Kentucky Agricultural Experiment Station, Maryland Agricultural Experiment Station, Virginia Polytechnic Institute and State University, North Carolina State University, and the USDA-ARS. KY06C-11-3-10 carries exotic FHB resistance alleles from Chinese spring wheat 'Ning7840' at Fhb1, and at QTL on chromosomes 5A and 2DL. These QTL, backcrossed into 'McCormick'-which itself has nonexotic, native moderate resistance-reduced FHB spike symptoms, percentage Fusarium-damaged kernels, and concentration of the mycotoxin deoxynivalenol (DON). KY06C-11-3-10 has additionally been selected for yield, test weight, heading date, height, milling and baking quality, and resistance to lodging. The combination of exotic resistance QTL, moderately resistant genetic background, widespread adaptation, and competitive agronomic and quality characteristics makes KY06C-11-3-10 a useful germplasm for wheat breeders.