‘Vision 45’ (Reg. No. CV-1110, PI 667642), is a hard red winter (HRW) wheat (Triticum aestivum L.) cultivar that was developed and tested as VA07HRW-45 and released by the Virginia Agricultural Experiment Station in 2012. Vision 45 was derived from the cross ‘Provinciale’/‘Vision 10’ using a modified bulk breeding method. It was tested in replicated yield trials in Virginia (2008–2014) and in the USDA-ARS Uniform Bread Wheat (UBW) Trials (2009–2014). Vision 45 is a widely adapted, high-yielding, awned, semidwarf (unknown Rht gene) HRW wheat with mid- to late-season spike emergence, strong straw strength, and resistance or moderate resistance to diseases prevalent in the mid-Atlanticregion. In Virginia, Vision 45 was the highest-yielding hard winter wheat over a 4-yr period, having an average grain yield (5499 kg ha-1) that was slightly higher than the soft red winter wheat cultivar Tribute (PI 654422), which was 5181 kg ha-1. Over 6 yr and 97 environments in the UBW Trials, Vision 45 had an average grain y eld of 4924 kg ha-1, one ofthe highest-yielding hard wheat cultivars. Vision 45 has good end-use quality on the basis of comparisons with the HRW wheat check cultivar Jagger (PI 593688), for flour yield (70.7 versus 70.3 g 100 g-1), flour protein (10.5 versus 10.6 g 100 g−1), flour water absorption (60.7 vs. 61.3 g 100 g−1), dough mixing tolerance (2.7 versus 2.7), pup-loaf volume (798 versus 773 cm3), and crumb grain scores (3.3 versus 2.8).