TY - JOUR
T1 - Regular Wine Consumption in Chronic Heart Failure
T2 - Impact on Outcomes, Quality of Life, and Circulating Biomarkers
AU - GISSI-HF Investigators
AU - Cosmi, Franco
AU - Di Giulio, Paola
AU - Masson, Serge
AU - Finzi, Andrea
AU - Marfisi, Rosa Maria
AU - Cosmi, Deborah
AU - Scarano, Marco
AU - Tognoni, Gianni
AU - Maggioni, Aldo P.
AU - Porcu, Maurizio
AU - Boni, Silvana
AU - Cutrupi, Giovanni
AU - Tavazzi, Luigi
AU - Latini, Roberto
AU - Barlera, S.
AU - Franzosi, M. G.
AU - Lucci, D.
AU - Marchioli, R.
AU - Nicolosi, G. L.
AU - Yusuf, S.
AU - Camerini, F.
AU - Cohn, J. N.
AU - Decarli, A.
AU - Pitt, B.
AU - Sleight, P.
AU - Poole-Wilson, P. A.
AU - Geraci, E.
AU - Scherillo, M.
AU - Fabbri, G.
AU - Bartolomei, B.
AU - Bertoli, D.
AU - Cobelli, F.
AU - Fresco, C.
AU - Ledda, A.
AU - Levantesi, G.
AU - Opasich, C.
AU - Rusconi, F.
AU - Sinagra, G.
AU - Turazza, F.
AU - Volpi, A.
AU - Ceseri, M.
AU - Alongi, G.
AU - Atzori, A.
AU - Bambi, F.
AU - Bastarolo, D.
AU - Bianchini, F.
AU - Cangioli, I.
AU - Canu, V.
AU - Caporusso, C.
AU - Cenni, G.
N1 - Publisher Copyright:
© 2015 American Heart Association, Inc.
PY - 2015/5/4
Y1 - 2015/5/4
N2 - Background-Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results-A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P<0.0001), less frequent symptoms of depression (Geriatric Depression Scale, adjusted P=0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P<0.0001, and pentraxin-3, P=0.01) after adjusting for possible confounders. Conclusions-We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT0033633.
AB - Background-Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results-A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P<0.0001), less frequent symptoms of depression (Geriatric Depression Scale, adjusted P=0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P<0.0001, and pentraxin-3, P=0.01) after adjusting for possible confounders. Conclusions-We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT0033633.
KW - biological markers
KW - quality of life
KW - wine
UR - http://www.scopus.com/inward/record.url?scp=84938509098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938509098&partnerID=8YFLogxK
U2 - 10.1161/CIRCHEARTFAILURE.114.002091
DO - 10.1161/CIRCHEARTFAILURE.114.002091
M3 - Article
C2 - 25925415
AN - SCOPUS:84938509098
SN - 1941-3289
VL - 8
SP - 428
EP - 437
JO - Circulation: Heart Failure
JF - Circulation: Heart Failure
IS - 3
ER -