Regulated expression and binding of three VLA (β1) integrin receptors on T cells

Yoji Shimizu, Gijs A. Van Seventer, Kevin J. Horgan, Stephen Shaw

Research output: Contribution to journalArticlepeer-review

527 Scopus citations

Abstract

REGULATED adhesion of T cells to extracellular matrix (ECM) proteins is likely to be essential in T cell migration. Constitutive binding of various other cell types to ECM components is mediated by members of the VLA (very late antigen) subfamily of integrins1-4. We describe here the regulated binding of resting CD4+ human T cells to ECM through three VLA integrins: VLA-4 (refs 5, 6) and VLA-5 (réf. 7) binding to fibronectin (FN), and a novel pathway of VLA-6 binding to laminin (LN). Binding to ECM is regulated in two ways. First, unlike other VLA-mediated interactions, VLA binding activity of the T cells is rapidly and dramatically augmented with cell activation without change in level of expression of the VLA molecules. Second, binding is regulated with T-cell differentiation ; memory T cells express three- to fourfold more VLA-4, VLA-5, and VLA-6 than do naive cells, and bind more efficiently through them to FN and LN.

Original languageEnglish (US)
Pages (from-to)250-253
Number of pages4
JournalNature
Volume345
Issue number6272
DOIs
StatePublished - Jan 1 1990

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