TY - JOUR
T1 - Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-Ribose) polymerase-1
T2 - Possible targets for drug-based therapies
AU - Wacker, David A.
AU - Frizzell, Kristine M.
AU - Zhang, Tong
AU - Kraus, W. Lee
N1 - Publisher Copyright:
© 2007 Springer.
PY - 2007
Y1 - 2007
N2 - Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD+ molecules on target proteins. PARP-1 plays roles in a variety of genomic processes, including the regulation of chromatin structure and transcription in response to specific cellular signals. PARP-1 also plays important roles in many stress-induced disease states. In this chapter, we review the molecular and cellular aspects of PARP-1’s chromatin-modulating activities, as well as the impact that these chromatin-modulating activities have on the regulation of gene expression. In addition, we highlight the potential therapeutic use of drugs that target PARP-1’s enzymatic activity for the treatment of human diseases.
AB - Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD+ molecules on target proteins. PARP-1 plays roles in a variety of genomic processes, including the regulation of chromatin structure and transcription in response to specific cellular signals. PARP-1 also plays important roles in many stress-induced disease states. In this chapter, we review the molecular and cellular aspects of PARP-1’s chromatin-modulating activities, as well as the impact that these chromatin-modulating activities have on the regulation of gene expression. In addition, we highlight the potential therapeutic use of drugs that target PARP-1’s enzymatic activity for the treatment of human diseases.
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U2 - 10.1007/1-4020-5466-1_3
DO - 10.1007/1-4020-5466-1_3
M3 - Article
C2 - 17484123
AN - SCOPUS:34249827266
SN - 0306-0225
VL - 41
SP - 45
EP - 69
JO - Subcellular Biochemistry
JF - Subcellular Biochemistry
ER -