Regulation of Nlrp3 inflammasome by dietary metabolites

Christina Camell, Emily Goldberg, Vishwa Deep Dixit

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The bidirectional communication between innate immune cells and energy metabolism is now widely appreciated to regulate homeostasis as well as chronic diseases that emerge from dysregulated inflammation. Macronutrients-derived from diet or endogenous pathways that generate and divert metabolites into energetic or biosynthetic pathways - regulate the initiation, duration and cessation of the inflammatory response. The NLRP3 inflammasome is an important innate sensor of structurally diverse metabolic damage-associated molecular patterns (DAMPs) that has been implicated in a wide range of inflammatory disorders associated with caloric excess, adiposity and aging. Understanding the regulators of immune-metabolic interactions and their contribution towards chronic disease mechanisms, therefore, has the potential to reduce disease pathology, improve quality of life in elderly and promote the extension of healthspan. Just as specialized subsets of immune cells dampen inflammation through the production of negative regulatory cytokines; specific immunoregulatory metabolites can deactivate inflammasome-mediated immune activation. Here, we highlight the role of energy substrates, alternative fuels and metabolic DAMPs in the regulation of the NLRP3 inflammasome and discuss potential dietary interventions that may impact sterile inflammatory disease.

Original languageEnglish (US)
Pages (from-to)334-342
Number of pages9
JournalSeminars in Immunology
Volume27
Issue number5
DOIs
StatePublished - Sep 1 2015

Bibliographical note

Funding Information:
Dixit lab is supported in part by National Institutes of Health grants DK090556 , AG043608 and AI105097 . CC is supported by Supplemental Funding from NIH-AG043608.

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

  • DAMP
  • Dietary intervention
  • Fatty acids
  • Ketones
  • Macrophage
  • Metabolite
  • Nlrp3 inflammasome
  • Sterile inflammation

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