Regulation of the transcription of G protein-coupled receptor genes

Cheol Kyu T Hwang, Ping-Yee Law, Li-Na Wei, Horace H Loh

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) participate in a variety of physiological functions and are major targets of pharmaceutical drugs. More than 600 GPCRs have been identified in the human genome. Although GPCRs are expressed in multiple tissues and individual tissues express multiple GPCRs, many have exclusive or increased expression within the central nervous system (CNS). These unique and diverse expression patterns raise fundamental questions as to the molecular mechanisms underlying the tissue/cell-specific distribution of GPCRs as well as the means by which their expression is altered in response to stimuli. Gene expression in mammals involves both transcriptional and posttranscriptional mechanisms. In this chapter, we provide an overview of the transcriptional regulation of GPCRs and discuss both established and emerging techniques to study transcriptional regulation.

Original languageEnglish (US)
Title of host publicationMethods for the Discovery and Characterization of G Protein-Coupled Receptors
EditorsCraig W. Stevens
Pages49-69
Number of pages21
DOIs
StatePublished - Aug 4 2011

Publication series

NameNeuromethods
Volume60
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • ChIP-on-chip
  • Chromatin immunoprecipitation
  • Electrophoretic mobility shift assay
  • Epigenetic
  • G protein-coupled receptor
  • Gene expression
  • Histone

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