Metabolik sendromlu hastalarda ortalama trombosit hacminin subklinik ateroskleroz ile ilişkisi

Translated title of the contribution: Relation between mean platelet volume and subclinical atherosclerosis in patients with metabolic syndrome

Ali Riza Gülcan, Mustafa Serkan Karakaş, Bariş Akdemir, Mustafa Uçar, Refik Emre Altekin, Hüseyin Yilmaz

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Objectives: Metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. There is evidence of platelet activation in MetS. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. Therefore, we investigated the possible association between subclinical atherosclerosis, as evaluated by carotid intima-media thickness (CIMT) measurement and MPV, in MetS patients. Study design: Seventy-four patients with MetS were enrolled in the study. Patients were divided into two groups according to CIMT measurement: 35 patients with CIMT ≥1.0 mm were in Group 1 and 39 patients with CIMT <1.0 mm were in Group 2. MPV was measured using an automated blood cell counter. Results: The MPV level was significantly higher in patients with CIMT ≥1.0 mm than in patients with CIMT <1.0 mm (8.2±0.7 vs. 7.8±0.6 fl; p=0.01). In our study, we observed that platelet count was lower in KIMK ≥1.0 mm group and this finding was also found to be statistically significant. Conclusion: The risk of atherosclerosis could be shown by following the MPV values in MetS patients. Therefore, our results suggest that MPV is an important marker for early detection of atherosclerotic risk in patients with MetS.

Translated title of the contributionRelation between mean platelet volume and subclinical atherosclerosis in patients with metabolic syndrome
Original languageTurkish
Pages (from-to)22-28
Number of pages7
JournalTurk Kardiyoloji Dernegi Arsivi
Volume42
Issue number1
DOIs
StatePublished - 2014

Keywords

  • Atherosclerosis
  • Blood platelets/pathology
  • Metabolic syndrome X
  • Platelet activation
  • Platelet count

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