Relationship between age, gender, and race in patients presenting with myasthenia gravis with only ocular manifestations

Jason H. Peragallo, Elena Bitrian, Mark J. Kupersmith, Fritz Zimprich, Thomas J. Whittaker, Michael S. Lee, Beau B. Bruce

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: The demographic associations among patients presenting with myasthenia gravis with only ocular manifestations (OMG) is not clear. Methods: In this 5-center case series, we collected the race, gender, and age at diagnosis of patients diagnosed with myasthenia gravis who had no signs or symptoms of generalized myasthenia gravis (GMG). An a priori sample size calculation determined that 140 patients were required to accept that there was a ≤10-year difference in mean age (equivalence testing: power 90%, α = 0.05). Robust Bayesian analysis and linear regression were applied to evaluate whether age differed by gender or race. Results: Of 433 patients included, 258 (60%) were men. Mean age among men was 57 years (SD = 19) and 52 years (SD = 21) among women. The 95% credible interval (CI) (Bayesian equivalent of confidence interval) was 0.8-8.7 years for mean age, and there was a 99.6% probability that the mean difference in age between sexes was <10 years. Race was documented in 376 (68 [18%] non-Caucasian). Caucasians were 17.3 years older than non-Caucasians at diagnosis (95% CI, 12.2-22.3 y; P < 0.001) controlling for gender. There was no additive interaction of gender and race (P = 0.74). There was a bimodal distribution for women peaking around 30 and 60 years. Men had a left skewed unimodal age distribution peaking at age 70. Conclusions: The distribution of age at presentation in patients with OMG is different between men and women, similar to GMG. Non-Caucasian patients tend to develop OMG at a younger age.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalJournal of Neuro-Ophthalmology
Volume36
Issue number1
DOIs
StatePublished - 2016

Bibliographical note

Funding Information:
J. H. Peragallo is supported by a departmental grant from Research to Prevent Blindness. E. Bitrian is supported by a grant from the Vitreoretinal Surgery Foundation. M. J. Kupersmith is supported by grants U10 EY017281-01A1, Kriser Foundation, Empire Clinical Research Investigator Program (ERIP), and U10EY017281-06S2. M. S. Lee is supported by an unrestricted grant from Research to Prevent Blindness. B. B. Bruce is supported by an NIH/NEI grant K23EY019341, Research to Prevent Blindness, and is a consultant for Bayer and MedImmune. This study was not industry supported. The other authors report no conflicts of interest.

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