Relationship between the P3 event-related potential, its associated time-frequency components, and externalizing psychopathology

Casey S. Gilmore, Stephen M. Malone, Edward M. Bernat, William G. Iacono

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

P3 amplitude reduction (P3-AR) is associated with biological vulnerability to a spectrum of externalizing disorders, such as ADHD, conduct disorder, and substance use disorders. P3, however, is generally characterized as a broad activation involving multiple neurophysiological processes. One approach to separating P3-related processes is time-frequency (TF) analysis. The current study used a novel PCA-based TF analysis method to investigate relationships between P3, its associated TF components, and externalizing in a community-based sample of adolescent males. Results showed that 1) alone, P3 and each TF-PCA derived component could successfully discriminate diagnostic groups from controls, and 2) delta components in specific time ranges accounted for variance beyond that accounted for by P3. One delta component was associated with all diagnostic groups, suggesting it may represent a more parsimonious endophenotype for externalizing than P3-AR.

Original languageEnglish (US)
Pages (from-to)123-132
Number of pages10
JournalPsychophysiology
Volume47
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • ADHD
  • Conduct disorder
  • Delta
  • Externalizing
  • Oppositional defiant disorder
  • P3
  • PCA
  • Substance use disorder
  • Theta
  • Time-frequency

Fingerprint

Dive into the research topics of 'Relationship between the P3 event-related potential, its associated time-frequency components, and externalizing psychopathology'. Together they form a unique fingerprint.

Cite this