Reliability of taurine concentrations measured in single urine samples obtained from dogs eight hours after eating

Sherry Sanderson, Kathy Gross, Jody Lulich, Carl Osborne, Phillip Ogburn, Mary Ella Pierpont, Lori Koehler, Laurie Swanson, Kathy Bird, Lisa Ulrich

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective - To evaluate the reliability of taurine concentrations measured in a single urine sample obtained from dogs 8 hours after eating, compared with taurine concentrations measured in 24-hour urine samples. Animals - 18 healthy Beagles. Procedure - After emptying the urinary bladder by transurethral catheterization, dogs were fed a canned maintenance diet. Approximately 8 hours later, urine, plasma, and serum samples were obtained for determination of fractional urinary excretion of taurine and urine taurine-to-creatinine concentration ratios (Utaur:Ucr). Results were compared with 24-hour urinary taurine excretion rate. Results - Unbound and total fractional urinary taurine excretion correlated well with unbound and total 24-hour urinary taurine excretion. However, bound fractional urinary taurine excretion correlated poorly with bound 24-hour urinary taurine excretion. Unbound and total Utaur:Ucr, correlated well with unbound and total 24-hour urinary taurine excretion. However, bound Utaur:Ucr correlated poorly with bound 24-hour urinary taurine excretion. Conclusion and Clinical Relevance - Fractional urinary excretion of unbound and total taurine, and unbound and total Utaur:Ucr are reliable indicators of 24-hour urinary unbound and total taurine excretion in healthy dogs. However, determination of 24-hour urinary taurine excretion is recommended for evaluating urinary bound taurine concentrations of dogs. (Am J Vet Res 1999;60:186-189).

Original languageEnglish (US)
Pages (from-to)186-189
Number of pages4
JournalAmerican journal of veterinary research
Volume60
Issue number2
StatePublished - Feb 1 1999

Fingerprint

Dive into the research topics of 'Reliability of taurine concentrations measured in single urine samples obtained from dogs eight hours after eating'. Together they form a unique fingerprint.

Cite this