TY - JOUR
T1 - Reliability of taurine concentrations measured in single urine samples obtained from dogs eight hours after eating
AU - Sanderson, Sherry
AU - Gross, Kathy
AU - Lulich, Jody
AU - Osborne, Carl
AU - Ogburn, Phillip
AU - Pierpont, Mary Ella
AU - Koehler, Lori
AU - Swanson, Laurie
AU - Bird, Kathy
AU - Ulrich, Lisa
PY - 1999/2
Y1 - 1999/2
N2 - Objective - To evaluate the reliability of taurine concentrations measured in a single urine sample obtained from dogs 8 hours after eating, compared with taurine concentrations measured in 24-hour urine samples. Animals - 18 healthy Beagles. Procedure - After emptying the urinary bladder by transurethral catheterization, dogs were fed a canned maintenance diet. Approximately 8 hours later, urine, plasma, and serum samples were obtained for determination of fractional urinary excretion of taurine and urine taurine-to-creatinine concentration ratios (Utaur:Ucr). Results were compared with 24-hour urinary taurine excretion rate. Results - Unbound and total fractional urinary taurine excretion correlated well with unbound and total 24-hour urinary taurine excretion. However, bound fractional urinary taurine excretion correlated poorly with bound 24-hour urinary taurine excretion. Unbound and total Utaur:Ucr, correlated well with unbound and total 24-hour urinary taurine excretion. However, bound Utaur:Ucr correlated poorly with bound 24-hour urinary taurine excretion. Conclusion and Clinical Relevance - Fractional urinary excretion of unbound and total taurine, and unbound and total Utaur:Ucr are reliable indicators of 24-hour urinary unbound and total taurine excretion in healthy dogs. However, determination of 24-hour urinary taurine excretion is recommended for evaluating urinary bound taurine concentrations of dogs. (Am J Vet Res 1999;60:186-189).
AB - Objective - To evaluate the reliability of taurine concentrations measured in a single urine sample obtained from dogs 8 hours after eating, compared with taurine concentrations measured in 24-hour urine samples. Animals - 18 healthy Beagles. Procedure - After emptying the urinary bladder by transurethral catheterization, dogs were fed a canned maintenance diet. Approximately 8 hours later, urine, plasma, and serum samples were obtained for determination of fractional urinary excretion of taurine and urine taurine-to-creatinine concentration ratios (Utaur:Ucr). Results were compared with 24-hour urinary taurine excretion rate. Results - Unbound and total fractional urinary taurine excretion correlated well with unbound and total 24-hour urinary taurine excretion. However, bound fractional urinary taurine excretion correlated poorly with bound 24-hour urinary taurine excretion. Unbound and total Utaur:Ucr, correlated well with unbound and total 24-hour urinary taurine excretion. However, bound Utaur:Ucr correlated poorly with bound 24-hour urinary taurine excretion. Conclusion and Clinical Relevance - Fractional urinary excretion of unbound and total taurine, and unbound and total Utaur:Ucr are reliable indicators of 24-hour urinary unbound and total taurine excretion in healthy dogs. However, determination of 24-hour urinary taurine excretion is recommended for evaluating urinary bound taurine concentrations of dogs. (Am J Vet Res 1999;60:186-189).
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M3 - Article
C2 - 10048549
AN - SCOPUS:0033071711
SN - 0002-9645
VL - 60
SP - 186
EP - 189
JO - American journal of veterinary research
JF - American journal of veterinary research
IS - 2
ER -