Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe

Chuanhe Yu; Michael J. Bonaduce; Amar J.S. Klar

doi:10.1534/genetics.112.138727

Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe

Chuanhe Yu, Michael J. Bonaduce, Amar J.S. Klar

Research output: Contribution to journal › Comment/debate › peer-review

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Abstract

A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion.

Original language	English (US)
Pages (from-to)	285-289
Number of pages	5
Journal	Genetics
Volume	191
Issue number	1
DOIs	https://doi.org/10.1534/genetics.112.138727
State	Published - May 2012
Externally published	Yes

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abstract = "A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion.",

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Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe

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