Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe

Chuanhe Yu, Michael J. Bonaduce, Amar J.S. Klar

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalGenetics
Volume191
Issue number1
DOIs
StatePublished - May 2012
Externally publishedYes

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