TY - JOUR
T1 - Renal transplantation for patients 60 years of age or older
T2 - A single-institution experience
AU - Benedetti, Enrico
AU - Matas, Arthur J.
AU - Hakim, Nadey
AU - Fasola, Carlos
AU - Gillingham, Kristen
AU - McHugh, Lois
AU - Najarian, John S.
PY - 1994/10
Y1 - 1994/10
N2 - Objective: The authors reviewed renal transplant outcomes in recipients 60 years of age or older. Background: Before cyclosporine, patients older than 45 years of age were considered to be at high risk for transplantation. With cyclosporine, the age limits for transplantation have expanded. Methods: The authors compared patient and graft survival, hospital stay, the incidence of rejection and rehospitalization, and the cause of graft loss for primary kidney recipients 60 years of age or older versus those 18 to 59 years of age. For those patients ≥ 60 years transplanted since 1985, the authors analyzed pretransplant extrarenal disease and its impact on post-transplant outcome. In addition, all surviving recipients ≥ 60 years completed a medical outcome survey (SF-36). Results: Patient and graft survival for those ≥ 60 years of age versus those 18 to 59 years of age were similar 3 years after transplant. Subsequently, mortality increased for the older recipients. Death-censored graft survival was identical in the two groups. There were no differences in the cause of graft loss. Those 60 years of age or older had a longer initial hospitalization, but had fewer rejection episodes and fewer rehospitalizations. Quality of life for recipients 60 years of age or older was similar to the age-matched U.S. population. Conclusion: Renal transplantation is successful for recipients 60 years of age or older. Most of them had extrarenal disease at the time of transplantation; however, extrarenal disease was not an important predictor of outcome and should not be used as an exclusion criterion. Post-transplant quality of life is excellent.
AB - Objective: The authors reviewed renal transplant outcomes in recipients 60 years of age or older. Background: Before cyclosporine, patients older than 45 years of age were considered to be at high risk for transplantation. With cyclosporine, the age limits for transplantation have expanded. Methods: The authors compared patient and graft survival, hospital stay, the incidence of rejection and rehospitalization, and the cause of graft loss for primary kidney recipients 60 years of age or older versus those 18 to 59 years of age. For those patients ≥ 60 years transplanted since 1985, the authors analyzed pretransplant extrarenal disease and its impact on post-transplant outcome. In addition, all surviving recipients ≥ 60 years completed a medical outcome survey (SF-36). Results: Patient and graft survival for those ≥ 60 years of age versus those 18 to 59 years of age were similar 3 years after transplant. Subsequently, mortality increased for the older recipients. Death-censored graft survival was identical in the two groups. There were no differences in the cause of graft loss. Those 60 years of age or older had a longer initial hospitalization, but had fewer rejection episodes and fewer rehospitalizations. Quality of life for recipients 60 years of age or older was similar to the age-matched U.S. population. Conclusion: Renal transplantation is successful for recipients 60 years of age or older. Most of them had extrarenal disease at the time of transplantation; however, extrarenal disease was not an important predictor of outcome and should not be used as an exclusion criterion. Post-transplant quality of life is excellent.
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U2 - 10.1097/00000658-199410000-00004
DO - 10.1097/00000658-199410000-00004
M3 - Article
C2 - 7944657
AN - SCOPUS:0028072241
SN - 0003-4932
VL - 220
SP - 445
EP - 460
JO - Annals of surgery
JF - Annals of surgery
IS - 4
ER -