Repairing brain after stroke: A review on post-ischemic neurogenesis

Charles Wiltrout; Bradley Lang; Yiping Yan; Robert J. Dempsey; Raghu Vemuganti

doi:10.1016/j.neuint.2007.04.011

Repairing brain after stroke: A review on post-ischemic neurogenesis

Charles Wiltrout, Bradley Lang, Yiping Yan, Robert J. Dempsey, Raghu Vemuganti

Research output: Contribution to journal › Short survey › peer-review

153 Scopus citations

Abstract

Stroke is devastating as currently no therapies are available that can prevent stroke-induced neurological dysfunction in humans. With the recent observations that acute insults to adult brain stimulate new neuronal formation in various species of animals, optimism is building for a possible regeneration of stroke-damaged brain. This article reviewed the advances in the understanding of the molecular mechanisms of the various steps of neurogenesis with an emphasis on the endogenous mediators and exogenous promoters of neural progenitor proliferation, migration and survival in the post-ischemic adult brain.

Original language	English (US)
Pages (from-to)	1028-1041
Number of pages	14
Journal	Neurochemistry International
Volume	50
Issue number	7-8
DOIs	https://doi.org/10.1016/j.neuint.2007.04.011
State	Published - Jun 2007
Externally published	Yes

Bibliographical note

Funding Information:
The authors’ laboratories were funded by grants from the United States National Institutes of Health, the American Heart Association and the University of Wisconsin Medical School.

Keywords

Cerebral ischemia
Growth factors
Neural progenitor proliferation
Stem cell migration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Repairing brain after stroke: A review on post-ischemic neurogenesis",

abstract = "Stroke is devastating as currently no therapies are available that can prevent stroke-induced neurological dysfunction in humans. With the recent observations that acute insults to adult brain stimulate new neuronal formation in various species of animals, optimism is building for a possible regeneration of stroke-damaged brain. This article reviewed the advances in the understanding of the molecular mechanisms of the various steps of neurogenesis with an emphasis on the endogenous mediators and exogenous promoters of neural progenitor proliferation, migration and survival in the post-ischemic adult brain.",

keywords = "Cerebral ischemia, Growth factors, Neural progenitor proliferation, Stem cell migration",

author = "Charles Wiltrout and Bradley Lang and Yiping Yan and Dempsey, {Robert J.} and Raghu Vemuganti",

note = "Funding Information: The authors{\textquoteright} laboratories were funded by grants from the United States National Institutes of Health, the American Heart Association and the University of Wisconsin Medical School.",

year = "2007",

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doi = "10.1016/j.neuint.2007.04.011",

language = "English (US)",

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T2 - A review on post-ischemic neurogenesis

AU - Wiltrout, Charles

AU - Lang, Bradley

AU - Yan, Yiping

AU - Dempsey, Robert J.

AU - Vemuganti, Raghu

N1 - Funding Information: The authors’ laboratories were funded by grants from the United States National Institutes of Health, the American Heart Association and the University of Wisconsin Medical School.

PY - 2007/6

Y1 - 2007/6

N2 - Stroke is devastating as currently no therapies are available that can prevent stroke-induced neurological dysfunction in humans. With the recent observations that acute insults to adult brain stimulate new neuronal formation in various species of animals, optimism is building for a possible regeneration of stroke-damaged brain. This article reviewed the advances in the understanding of the molecular mechanisms of the various steps of neurogenesis with an emphasis on the endogenous mediators and exogenous promoters of neural progenitor proliferation, migration and survival in the post-ischemic adult brain.

AB - Stroke is devastating as currently no therapies are available that can prevent stroke-induced neurological dysfunction in humans. With the recent observations that acute insults to adult brain stimulate new neuronal formation in various species of animals, optimism is building for a possible regeneration of stroke-damaged brain. This article reviewed the advances in the understanding of the molecular mechanisms of the various steps of neurogenesis with an emphasis on the endogenous mediators and exogenous promoters of neural progenitor proliferation, migration and survival in the post-ischemic adult brain.

KW - Cerebral ischemia

KW - Growth factors

KW - Neural progenitor proliferation

KW - Stem cell migration

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Repairing brain after stroke: A review on post-ischemic neurogenesis

Abstract

Bibliographical note

Keywords

UN SDGs

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