Replication of association between ELAVL4 and Parkinson disease: The Gene PD study

Anita L. DeStefano; Jeanne Latourelle; Mark F. Lew; Oksana Suchowersky; Christine Klein; Lawrence I. Golbe; Margery H. Mark; John H. Growdon; G. Fredrick Wooten; Ray Watts; Mark Guttman; Brad A. Racette; Joel S. Perlmutter; Lynn Marlor; Holly A. Shill; Carlos Singer; Stefano Goldwurm; Gianni Pezzoli; Marie H. Saint-Hilaire; Audrey E. Hendricks; Adam Gower; Sally Williamson; Michael W. Nagle; Jemma B. Wilk; Tiffany Massood; Karen W. Huskey; Kenneth B. Baker; Ilia Itin; Irene Litvan; Garth Nicholson; Alastair Corbett; Martha Nance; Edward Drasby; Stuart Isaacson; David J. Burn; Patrick F. Chinnery; Peter P. Pramstaller; Jomana Al-hinti; Anette T. Moller; Karen Ostergaard; Scott J. Sherman; Richard Roxburgh; Barry Snow; John T. Slevin; Franca Cambi; James F. Gusella; Richard H. Myers

doi:10.1007/s00439-008-0526-4

Replication of association between ELAVL4 and Parkinson disease: The Gene PD study

Anita L. DeStefano, Jeanne Latourelle, Mark F. Lew, Oksana Suchowersky, Christine Klein, Lawrence I. Golbe, Margery H. Mark, John H. Growdon, G. Fredrick Wooten, Ray Watts, Mark Guttman, Brad A. Racette, Joel S. Perlmutter, Lynn Marlor, Holly A. Shill, Carlos Singer, Stefano Goldwurm, Gianni Pezzoli, Marie H. Saint-Hilaire, Audrey E. HendricksAdam Gower, Sally Williamson, Michael W. Nagle, Jemma B. Wilk, Tiffany Massood, Karen W. Huskey, Kenneth B. Baker, Ilia Itin, Irene Litvan, Garth Nicholson, Alastair Corbett, Martha Nance, Edward Drasby, Stuart Isaacson, David J. Burn, Patrick F. Chinnery, Peter P. Pramstaller, Jomana Al-hinti, Anette T. Moller, Karen Ostergaard, Scott J. Sherman, Richard Roxburgh, Barry Snow, John T. Slevin, Franca Cambi, James F. Gusella, Richard H. Myers

Neurology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the Gene PD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the Gene PD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.

Original language	English (US)
Pages (from-to)	95-99
Number of pages	5
Journal	Human Genetics
Volume	124
Issue number	1
DOIs	https://doi.org/10.1007/s00439-008-0526-4
State	Published - Aug 2008

Bibliographical note

Funding Information:
Acknowledgments This study was supported by PHS grant R01 NS36711-05 ‘‘Genetic Linkage Study in PD’’ and the Bumpus Foundation. The DNA samples contributed by the Parkinson Institute—Istituti Clinici di Perfezionamento, Milan, Italy, were from the ‘‘Human genetic bank of patients affected by PD and parkinsonisms,’’ supported by Italian Telethon grant n. GTF04007 and by the ‘‘Fondazione Grigioni per il Morbo di Parkinson.’’

Access

10.1007/s00439-008-0526-4

OpenUrl availability

Full text

Cite this

DeStefano, A. L., Latourelle, J., Lew, M. F., Suchowersky, O., Klein, C., Golbe, L. I., Mark, M. H., Growdon, J. H., Wooten, G. F., Watts, R., Guttman, M., Racette, B. A., Perlmutter, J. S., Marlor, L., Shill, H. A., Singer, C., Goldwurm, S., Pezzoli, G., Saint-Hilaire, M. H., ... Myers, R. H. (2008). Replication of association between ELAVL4 and Parkinson disease: The Gene PD study. Human Genetics, 124(1), 95-99. https://doi.org/10.1007/s00439-008-0526-4

DeStefano, AL, Latourelle, J, Lew, MF, Suchowersky, O, Klein, C, Golbe, LI, Mark, MH, Growdon, JH, Wooten, GF, Watts, R, Guttman, M, Racette, BA, Perlmutter, JS, Marlor, L, Shill, HA, Singer, C, Goldwurm, S, Pezzoli, G, Saint-Hilaire, MH, Hendricks, AE, Gower, A, Williamson, S, Nagle, MW, Wilk, JB, Massood, T, Huskey, KW, Baker, KB, Itin, I, Litvan, I, Nicholson, G, Corbett, A, Nance, M, Drasby, E, Isaacson, S, Burn, DJ, Chinnery, PF, Pramstaller, PP, Al-hinti, J, Moller, AT, Ostergaard, K, Sherman, SJ, Roxburgh, R, Snow, B, Slevin, JT, Cambi, F, Gusella, JF & Myers, RH 2008, 'Replication of association between ELAVL4 and Parkinson disease: The Gene PD study', Human Genetics, vol. 124, no. 1, pp. 95-99. https://doi.org/10.1007/s00439-008-0526-4

@article{be6f628a77d245d4bd2200c09549908b,

title = "Replication of association between ELAVL4 and Parkinson disease: The Gene PD study",

abstract = "Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the Gene PD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the Gene PD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.",

author = "DeStefano, {Anita L.} and Jeanne Latourelle and Lew, {Mark F.} and Oksana Suchowersky and Christine Klein and Golbe, {Lawrence I.} and Mark, {Margery H.} and Growdon, {John H.} and Wooten, {G. Fredrick} and Ray Watts and Mark Guttman and Racette, {Brad A.} and Perlmutter, {Joel S.} and Lynn Marlor and Shill, {Holly A.} and Carlos Singer and Stefano Goldwurm and Gianni Pezzoli and Saint-Hilaire, {Marie H.} and Hendricks, {Audrey E.} and Adam Gower and Sally Williamson and Nagle, {Michael W.} and Wilk, {Jemma B.} and Tiffany Massood and Huskey, {Karen W.} and Baker, {Kenneth B.} and Ilia Itin and Irene Litvan and Garth Nicholson and Alastair Corbett and Martha Nance and Edward Drasby and Stuart Isaacson and Burn, {David J.} and Chinnery, {Patrick F.} and Pramstaller, {Peter P.} and Jomana Al-hinti and Moller, {Anette T.} and Karen Ostergaard and Sherman, {Scott J.} and Richard Roxburgh and Barry Snow and Slevin, {John T.} and Franca Cambi and Gusella, {James F.} and Myers, {Richard H.}",

note = "Funding Information: Acknowledgments This study was supported by PHS grant R01 NS36711-05 {\textquoteleft}{\textquoteleft}Genetic Linkage Study in PD{\textquoteright}{\textquoteright} and the Bumpus Foundation. The DNA samples contributed by the Parkinson Institute—Istituti Clinici di Perfezionamento, Milan, Italy, were from the {\textquoteleft}{\textquoteleft}Human genetic bank of patients affected by PD and parkinsonisms,{\textquoteright}{\textquoteright} supported by Italian Telethon grant n. GTF04007 and by the {\textquoteleft}{\textquoteleft}Fondazione Grigioni per il Morbo di Parkinson.{\textquoteright}{\textquoteright}",

year = "2008",

month = aug,

doi = "10.1007/s00439-008-0526-4",

language = "English (US)",

volume = "124",

pages = "95--99",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Replication of association between ELAVL4 and Parkinson disease

T2 - The Gene PD study

AU - DeStefano, Anita L.

AU - Latourelle, Jeanne

AU - Lew, Mark F.

AU - Suchowersky, Oksana

AU - Klein, Christine

AU - Golbe, Lawrence I.

AU - Mark, Margery H.

AU - Growdon, John H.

AU - Wooten, G. Fredrick

AU - Watts, Ray

AU - Guttman, Mark

AU - Racette, Brad A.

AU - Perlmutter, Joel S.

AU - Marlor, Lynn

AU - Shill, Holly A.

AU - Singer, Carlos

AU - Goldwurm, Stefano

AU - Pezzoli, Gianni

AU - Saint-Hilaire, Marie H.

AU - Hendricks, Audrey E.

AU - Gower, Adam

AU - Williamson, Sally

AU - Nagle, Michael W.

AU - Wilk, Jemma B.

AU - Massood, Tiffany

AU - Huskey, Karen W.

AU - Baker, Kenneth B.

AU - Itin, Ilia

AU - Litvan, Irene

AU - Nicholson, Garth

AU - Corbett, Alastair

AU - Nance, Martha

AU - Drasby, Edward

AU - Isaacson, Stuart

AU - Burn, David J.

AU - Chinnery, Patrick F.

AU - Pramstaller, Peter P.

AU - Al-hinti, Jomana

AU - Moller, Anette T.

AU - Ostergaard, Karen

AU - Sherman, Scott J.

AU - Roxburgh, Richard

AU - Snow, Barry

AU - Slevin, John T.

AU - Cambi, Franca

AU - Gusella, James F.

AU - Myers, Richard H.

N1 - Funding Information: Acknowledgments This study was supported by PHS grant R01 NS36711-05 ‘‘Genetic Linkage Study in PD’’ and the Bumpus Foundation. The DNA samples contributed by the Parkinson Institute—Istituti Clinici di Perfezionamento, Milan, Italy, were from the ‘‘Human genetic bank of patients affected by PD and parkinsonisms,’’ supported by Italian Telethon grant n. GTF04007 and by the ‘‘Fondazione Grigioni per il Morbo di Parkinson.’’

PY - 2008/8

Y1 - 2008/8

N2 - Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the Gene PD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the Gene PD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.

AB - Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the Gene PD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the Gene PD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.

UR - http://www.scopus.com/inward/record.url?scp=46949098429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46949098429&partnerID=8YFLogxK

U2 - 10.1007/s00439-008-0526-4

DO - 10.1007/s00439-008-0526-4

M3 - Article

C2 - 18587682

AN - SCOPUS:46949098429

SN - 0340-6717

VL - 124

SP - 95

EP - 99

JO - Human Genetics

JF - Human Genetics

IS - 1

ER -

Replication of association between ELAVL4 and Parkinson disease: The Gene PD study

Abstract

Bibliographical note

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this