Bibliographical noteFunding Information:
Supported by the National Heart, Lung, and Blood Institute through grant R01 HL68201-01A1.
Disclosure of potential conflict of interest: A. D. Paltiel has received research support from the National Institutes of Health. S. T. Weiss has received research support from the National Institutes of Health and Genentech. A. L. Fuhlbrigge is on the speakers' bureau for GlaxoSmithKline and Merck, designed and analyzed studies for Novartis, was a member of Sepracor's Data Safety Monitoring Board, and has received research support from Boehringer Ingelheim, GlaxoSmithKline, and Merck. The rest of the authors have declared that they have no conflict of interest.