Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Jon Odorico; James Markmann; Douglas Melton; Julia Greenstein; Albert Hwa; Cristina Nostro; Alireza Rezania; Jose Oberholzer; Daniel Pipeleers; Luhan Yang; Chad Cowan; Danwei Huangfu; Dieter Egli; Uri Ben-David; Ludovic Vallier; Shane T. Grey; Qizhi Tang; Bart Roep; Camilo Ricordi; Ali Naji; Giuseppe Orlando; Daniel G. Anderson; Mark Poznansky; Barbara Ludwig; Alice Tomei; Dale L. Greiner; Melanie Graham; Melissa Carpenter; Giovanni Migliaccio; Kevin D'Amour; Bernhard Hering; Lorenzo Piemonti; Thierry Berney; Mike Rickels; Thomas Kay; Ann Adams

doi:10.1097/TP.0000000000002217

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Jon Odorico, James Markmann, Douglas Melton, Julia Greenstein, Albert Hwa, Cristina Nostro, Alireza Rezania, Jose Oberholzer, Daniel Pipeleers, Luhan Yang, Chad Cowan, Danwei Huangfu, Dieter Egli, Uri Ben-David, Ludovic Vallier, Shane T. Grey, Qizhi Tang, Bart Roep, Camilo Ricordi, Ali NajiGiuseppe Orlando, Daniel G. Anderson, Mark Poznansky, Barbara Ludwig, Alice Tomei, Dale L. Greiner, Melanie Graham, Melissa Carpenter, Giovanni Migliaccio, Kevin D'Amour, Bernhard Hering, Lorenzo Piemonti, Thierry Berney, Mike Rickels, Thomas Kay, Ann Adams

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Beta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased donor organ supply cannot possibly treat all those who could benefit from restoration of a normal beta cell mass, especially if immunosuppression were not required. Against this background, the International Pancreas and Islet Transplant Association in collaboration with the Harvard Stem Cell Institute, the Juvenile Diabetes Research Foundation (JDRF), and the Helmsley Foundation held a 2-day Key Opinion Leaders Meeting in Boston in 2016 to bring together experts in generating and transplanting beta cells derived from stem cells. The following summary highlights current technology, recent significant breakthroughs, unmet needs and roadblocks to stem cell-derived beta cell therapies, with the aim of spurring future preclinical collaborative investigations and progress toward the clinical application of stem cell-derived beta cells.

Original language	English (US)
Pages (from-to)	1223-1229
Number of pages	7
Journal	Transplantation
Volume	102
Issue number	8
DOIs	https://doi.org/10.1097/TP.0000000000002217
State	Published - Aug 1 2018

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© 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Journal Article
Research Support, Non-U.S. Gov't
Review

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/TP.0000000000002217

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775764

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Odorico, J., Markmann, J., Melton, D., Greenstein, J., Hwa, A., Nostro, C., Rezania, A., Oberholzer, J., Pipeleers, D., Yang, L., Cowan, C., Huangfu, D., Egli, D., Ben-David, U., Vallier, L., Grey, S. T., Tang, Q., Roep, B., Ricordi, C., ... Adams, A. (2018). Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation, 102(8), 1223-1229. https://doi.org/10.1097/TP.0000000000002217

Odorico, J, Markmann, J, Melton, D, Greenstein, J, Hwa, A, Nostro, C, Rezania, A, Oberholzer, J, Pipeleers, D, Yang, L, Cowan, C, Huangfu, D, Egli, D, Ben-David, U, Vallier, L, Grey, ST, Tang, Q, Roep, B, Ricordi, C, Naji, A, Orlando, G, Anderson, DG, Poznansky, M, Ludwig, B, Tomei, A, Greiner, DL, Graham, M, Carpenter, M, Migliaccio, G, D'Amour, K, Hering, B, Piemonti, L, Berney, T, Rickels, M, Kay, T & Adams, A 2018, 'Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells', Transplantation, vol. 102, no. 8, pp. 1223-1229. https://doi.org/10.1097/TP.0000000000002217

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Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

Abstract

Bibliographical note

PubMed: MeSH publication types

UN SDGs

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