Resistance to Thyroid Hormones: A Disorder Frequently Confused With Graves' Disease

John P Bantle, Steven Seeling, Cary N. Mariash, Robert A. Ulstrom, Jack H. Oppenheimer

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Five patients from two unrelated families were found to have goiter and elevated serum concentrations of thyroxine (T4) and triiodothyronine (T3) without symptoms or signs of hyperthyroidism. All had measurable concentrations of thyroid stimulating hormone (TSH), and in four who were tested, there was an increase in TSH concentration following thyrotropin releasing hormone (TRH) administration. We believe these five patients have general resistance to the effects of thyroid hormones and need elevated concentrations of T4 and T3 to maintain a eumetabolic state. Study of nuclear T3 receptors from cultured fibroblasts of one patient disclosed a normal equilibrium association constant and a maximal binding capacity that was greater than normal control values. These findings suggest that thyroid hormone resistance in this patient is not due to a decrease in either the affinity or the number of specific nuclear T3 receptors. This disorder can easily be confused with Graves' disease and result in inappropriate treatment for hyperthyroidism, as was the case in three of our patients.

Original languageEnglish (US)
Pages (from-to)1867-1871
Number of pages5
JournalArchives of Internal Medicine
Issue number10
StatePublished - Oct 1982

Fingerprint Dive into the research topics of 'Resistance to Thyroid Hormones: A Disorder Frequently Confused With Graves' Disease'. Together they form a unique fingerprint.

Cite this