Respiratory function and pulmonary lesions in pigs infected with porcine reproductive and respiratory syndrome virus

Judith Wagner; Annette Kneucker; Elisabeth Liebler-Tenorio; Vicky Fachinger; Melanie Glaser; Stefan Pesch; Michael P. Murtaugh; Petra Reinhold

doi:10.1016/j.tvjl.2009.12.022

Respiratory function and pulmonary lesions in pigs infected with porcine reproductive and respiratory syndrome virus

Judith Wagner, Annette Kneucker, Elisabeth Liebler-Tenorio, Vicky Fachinger, Melanie Glaser, Stefan Pesch, Michael P. Murtaugh, Petra Reinhold

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Pulmonary dysfunction was evaluated in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV, isolate VR-2332) and compared to clinical and pathological findings. Infected pigs developed fever, reduced appetite, respiratory distress and dullness at 9. days post-inoculation (dpi). Non-invasive pulmonary function tests using impulse oscillometry and rebreathing of test gases (He, CO) revealed peripheral airway obstruction, reduced lung compliance and reduced lung CO-transfer factor. PRRSV-induced pulmonary dysfunction was most marked at 9-18 dpi and was accompanied by a significantly increased respiratory rate and decreased tidal volume. Expiration was affected more than inspiration. On histopathological examination, multifocal areas of interstitial pneumonia (more severe and extensive at 10 dpi than 21 dpi) were identified as a possible structural basis for reduced lung compliance and gas exchange disturbances.

Original language	English (US)
Pages (from-to)	310-319
Number of pages	10
Journal	Veterinary Journal
Volume	187
Issue number	3
DOIs	https://doi.org/10.1016/j.tvjl.2009.12.022
State	Published - Mar 2011

Bibliographical note

Funding Information:
The authors are very grateful to Annelie Langenberg, Sylke Stahlberg, Ines Lemser and to all colleagues working in the team of the animal house (FLI Jena, Germany) for their skilful assistance during the study. Furthermore, the authors are thankful to colleagues of the Institute of Bacterial Infections and Zoonoses (IBIZ) in the ‘Friedrich-Loeffler-Institut’ (Jena, Germany), namely Dr. Ulrich Methner and his team for Salmonella spp. diagnosis and Dr. Astrid Raßbach and co-workers for performing bacterial screening for Pasteurella spp., Bordetella spp., Haemophilus spp. and APP. In addition, the authors thank Dr. Konrad Sachse and staff of the OIE Reference Laboratory for Chlamydiosis for Chlamydia spp. testing and Renate Haß for assaying Mycoplasma spp. This work was funded by the non-profit organisation ‘Akademie für Tiergesundheit e.V.’ (Germany), which provided a scholarship for Judith Wagner.

Keywords

Pathology
Pigs
Porcine reproductive and respiratory syndrome virus
Pulmonary function testing

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Pulmonary dysfunction was evaluated in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV, isolate VR-2332) and compared to clinical and pathological findings. Infected pigs developed fever, reduced appetite, respiratory distress and dullness at 9. days post-inoculation (dpi). Non-invasive pulmonary function tests using impulse oscillometry and rebreathing of test gases (He, CO) revealed peripheral airway obstruction, reduced lung compliance and reduced lung CO-transfer factor. PRRSV-induced pulmonary dysfunction was most marked at 9-18 dpi and was accompanied by a significantly increased respiratory rate and decreased tidal volume. Expiration was affected more than inspiration. On histopathological examination, multifocal areas of interstitial pneumonia (more severe and extensive at 10 dpi than 21 dpi) were identified as a possible structural basis for reduced lung compliance and gas exchange disturbances.",

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Respiratory function and pulmonary lesions in pigs infected with porcine reproductive and respiratory syndrome virus

Abstract

Bibliographical note

Keywords

UN SDGs

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