TY - JOUR
T1 - Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway
AU - Huang, Chuanshu
AU - Ma, Wei-Ya
AU - Goranson, Angela
AU - Dong, Zigang
PY - 1999
Y1 - 1999
N2 - Resveratrol, a plant constituent enriched in the skin of grapes, is one of the most promising agents for the prevention of cancer. However, the mechanism of the anti-carcinogenic activity of resveratrol is not well understood. Here we offer a possible explanation of its anti-cancer effect. Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53(+/+)), but not in p53-deficient (p53(-/-)) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis.
AB - Resveratrol, a plant constituent enriched in the skin of grapes, is one of the most promising agents for the prevention of cancer. However, the mechanism of the anti-carcinogenic activity of resveratrol is not well understood. Here we offer a possible explanation of its anti-cancer effect. Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53(+/+)), but not in p53-deficient (p53(-/-)) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis.
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U2 - 10.1093/carcin/20.2.237
DO - 10.1093/carcin/20.2.237
M3 - Article
C2 - 10069459
AN - SCOPUS:0032939164
SN - 0143-3334
VL - 20
SP - 237
EP - 242
JO - Carcinogenesis
JF - Carcinogenesis
IS - 2
ER -