Retroviral vector targeting to human immunodeficiency virus type 1- infected cells by receptor pseudotyping

Nikunj V. Somia; Hiroyuki Miyoshi; Mark J. Schmitt; Inder M. Verma

doi:10.1128/JVI.74.9.4420-4424.2000

Retroviral vector targeting to human immunodeficiency virus type 1- infected cells by receptor pseudotyping

Nikunj V. Somia, Hiroyuki Miyoshi, Mark J. Schmitt, Inder M. Verma

Genetics, Cell Biology and Development (TMED)

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25 Scopus citations

Abstract

We report the generation of retroviral vectors based on Moloney murine leukemia virus that specifically transduce cells infected with T-cell-tropic human immunodeficiency virus type 1 (HIV-1). This vector was pseudotyped with T-cell-tropic HIV-1 receptors CD4 and CXCR4. We demonstrate that transduction is contingent upon HIV-1 gp120 and gp41 expression.

Original language	English (US)
Pages (from-to)	4420-4424
Number of pages	5
Journal	Journal of virology
Volume	74
Issue number	9
DOIs	https://doi.org/10.1128/JVI.74.9.4420-4424.2000
State	Published - 2000

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abstract = "We report the generation of retroviral vectors based on Moloney murine leukemia virus that specifically transduce cells infected with T-cell-tropic human immunodeficiency virus type 1 (HIV-1). This vector was pseudotyped with T-cell-tropic HIV-1 receptors CD4 and CXCR4. We demonstrate that transduction is contingent upon HIV-1 gp120 and gp41 expression.",

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Retroviral vector targeting to human immunodeficiency virus type 1- infected cells by receptor pseudotyping

Abstract

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