TY - JOUR
T1 - Revascularization improves survival in ischemic cardiomyopathy regardless of electrocardiographic criteria for prior small-to-medium myocardial infarcts
AU - Shah, Bimal R.
AU - Velazquez, Eric
AU - Shaw, Linda K.
AU - Bart, Bradley A
AU - O'Connor, Christopher
AU - Wagner, Galen S.
PY - 2002
Y1 - 2002
N2 - Background: The purpose of the current study was to determine whether survival after revascularization (coronary artery bypass grafting or percutaneous transluminal coronary angioplasty) is influenced by the extent of electrocardiographic (ECG) evidence of previous myocardial infarction (MI) in patients with ischemic cardiomyopathy by use of the 50-criteria, 31-point Selvester QRS scoring system. Methods: Patients with ischemic cardiomyopathy documented by a left ventricular ejection fraction (LVEF) ≤30% undergoing coronary angiography between January 1984 and July 1996, with no acute MI within the last 30 days, follow-up through 1996, and ≥75% occlusion in at least 1 major coronary artery at catheterization were included. These patients were subdivided on the basis of subsequent treatment: revascularization or no revascularization. The complete Selvester QRS system was applied to each patient's ECG and the subgroups were further subdivided by QRS score. Results: The 141 patients receiving revascularization had better survival at 5 years compared with the 298 patients receiving no revascularization (adjusted 5-year survival rate 73% vs 47%, P = .0001). No significant treatment differences were observed for low (≤3 points) versus high (>3 points) QRS levels in either of the 2 treatment groups (revascularized patients: P = .215, patients without revascularization: P = .126) between the 2 treatment groups. Although all patients had LVEF ≤30%, only 8% of patients had QRS scores > 10 points, the level that would be expected if the decrease in LVEF could be attributed entirely to infarcted myocardium. Conclusions: Hibernating myocardium may contribute significantly to the decreased function in patients with ischemic cardiomyopathy, and the QRS score cannot be used as an independent predictor of survival in those patients with a marked decrease in LVEF but small to moderate infarct sizes.
AB - Background: The purpose of the current study was to determine whether survival after revascularization (coronary artery bypass grafting or percutaneous transluminal coronary angioplasty) is influenced by the extent of electrocardiographic (ECG) evidence of previous myocardial infarction (MI) in patients with ischemic cardiomyopathy by use of the 50-criteria, 31-point Selvester QRS scoring system. Methods: Patients with ischemic cardiomyopathy documented by a left ventricular ejection fraction (LVEF) ≤30% undergoing coronary angiography between January 1984 and July 1996, with no acute MI within the last 30 days, follow-up through 1996, and ≥75% occlusion in at least 1 major coronary artery at catheterization were included. These patients were subdivided on the basis of subsequent treatment: revascularization or no revascularization. The complete Selvester QRS system was applied to each patient's ECG and the subgroups were further subdivided by QRS score. Results: The 141 patients receiving revascularization had better survival at 5 years compared with the 298 patients receiving no revascularization (adjusted 5-year survival rate 73% vs 47%, P = .0001). No significant treatment differences were observed for low (≤3 points) versus high (>3 points) QRS levels in either of the 2 treatment groups (revascularized patients: P = .215, patients without revascularization: P = .126) between the 2 treatment groups. Although all patients had LVEF ≤30%, only 8% of patients had QRS scores > 10 points, the level that would be expected if the decrease in LVEF could be attributed entirely to infarcted myocardium. Conclusions: Hibernating myocardium may contribute significantly to the decreased function in patients with ischemic cardiomyopathy, and the QRS score cannot be used as an independent predictor of survival in those patients with a marked decrease in LVEF but small to moderate infarct sizes.
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U2 - 10.1067/mhj.2002.119996
DO - 10.1067/mhj.2002.119996
M3 - Article
C2 - 11773920
AN - SCOPUS:0036144218
SN - 0002-8703
VL - 143
SP - 111
EP - 117
JO - American Heart Journal
JF - American Heart Journal
IS - 1
ER -