TY - JOUR
T1 - Reversal of lipopolysaccharide-analog-induced antibody suppression by anti-transforming growth factor β and indomethacin
AU - Odean, M. J.
AU - Johnson, A. G.
AU - Mohrman, M.
AU - Hasegawa, A.
PY - 1995
Y1 - 1995
N2 - Monophosphoryl lipid A and a synthetic, nontoxic monosaccharide analog of lipid A, termed GLA 60, both strongly suppressed antibody production when administered 1 to 2 days prior to antigen. Evidence is presented that this suppression was mediated by two cytokines, prostaglandin E and transforming growth factor β, because it was reversed by multiple injections of the cyclooxygenase inhibitor indomethacin and by in vitro addition of antibody to transforming growth factor β.
AB - Monophosphoryl lipid A and a synthetic, nontoxic monosaccharide analog of lipid A, termed GLA 60, both strongly suppressed antibody production when administered 1 to 2 days prior to antigen. Evidence is presented that this suppression was mediated by two cytokines, prostaglandin E and transforming growth factor β, because it was reversed by multiple injections of the cyclooxygenase inhibitor indomethacin and by in vitro addition of antibody to transforming growth factor β.
UR - http://www.scopus.com/inward/record.url?scp=0029006238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029006238&partnerID=8YFLogxK
U2 - 10.1128/iai.63.6.2371-2373.1995
DO - 10.1128/iai.63.6.2371-2373.1995
M3 - Article
C2 - 7768624
AN - SCOPUS:0029006238
SN - 0019-9567
VL - 63
SP - 2371
EP - 2373
JO - Infection and immunity
JF - Infection and immunity
IS - 6
ER -