Reversible and irreversible damage of the myocardium: Ischemia/reperfusion injury and cardioprotection

Brian T. Howard; Tinen L. Iles; James A. Coles; Daniel C. Sigg; Paul A. Iaizzo

doi:10.1007/978-3-319-19464-6_16

Reversible and irreversible damage of the myocardium: Ischemia/reperfusion injury and cardioprotection

Brian T. Howard, Tinen L. Iles, James A. Coles, Daniel C. Sigg, Paul A. Iaizzo

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6 Scopus citations

Abstract

Ischemia and reperfusion injuries can lead to major compromises in cardiac function. While the intent of many of the past cardioprotective therapies was to protect the myocardium from ischemic necrosis, it may be that reperfusion injury following ischemia may occur despite such preventative attempts. There are continued efforts to identify improvements in myocardial protective strategies (pre- and postconditioning), and their ultimate goals are to minimize the risk of cellular injuries to all types of patients undergoing cardiovascular therapies, treatments, or surgeries.

Original language	English (US)
Title of host publication	Handbook of Cardiac Anatomy, Physiology, and Devices, Third Edition
Publisher	Springer International Publishing
Pages	279-293
Number of pages	15
ISBN (Electronic)	9783319194646
ISBN (Print)	9783319194639
DOIs	https://doi.org/10.1007/978-3-319-19464-6_16
State	Published - Jan 1 2015

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2015.

Keywords

Cardioprotection
Hibernating myocardium
Ischemic preconditioning
Maimed myocardium
Myocardial ischemia
Myocardial stunning
Reperfusion injury
Silent ischemia

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10.1007/978-3-319-19464-6_16

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AU - Coles, James A.

AU - Sigg, Daniel C.

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KW - Ischemic preconditioning

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KW - Myocardial ischemia

KW - Myocardial stunning

KW - Reperfusion injury

KW - Silent ischemia

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Reversible and irreversible damage of the myocardium: Ischemia/reperfusion injury and cardioprotection

Abstract

Bibliographical note

Keywords

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