The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.
Bibliographical noteFunding Information:
This work was supported by the CounterACT Program, National Institutes of Health Office of the Director, and the National Institute of Neurological Disorders and Stroke, Grant 5 R21 NS076430. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Copyright 2013 Elsevier B.V., All rights reserved.
- 2-Methoxypyridinium compounds
- Reversible inhibition