Reversible inhibition of human acetylcholinesterase by methoxypyridinium species

Joseph J. Topczewski, Alexander M. Lodge, Sumana N. Yasapala, Maurice K. Payne, Pedrom M. Keshavarzi, Daniel M. Quinn

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.

Original languageEnglish (US)
Pages (from-to)5786-5789
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number21
DOIs
StatePublished - Nov 1 2013

Bibliographical note

Funding Information:
This work was supported by the CounterACT Program, National Institutes of Health Office of the Director, and the National Institute of Neurological Disorders and Stroke, Grant 5 R21 NS076430. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

  • 2-Methoxypyridinium compounds
  • Acetylcholinesterase
  • Reversible inhibition

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