TY - JOUR
T1 - Review of vasodilators in acute decompensated heart failure
T2 - the old and the new.
AU - Carlson, Michelle D.
AU - Eckman, Peter M
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2013/7
Y1 - 2013/7
N2 - Despite substantial improvements in treatment for chronic heart failure, morbidity and mortality for acute decompensated heart failure (ADHF) remain high. Treatment of ADHF is focused on controlling symptoms rather than improving long-term outcomes. The vasodilators nitroglycerin (NTG) and sodium nitroprusside (SNP) have been used in ADHF for decades, but, since the development of nesiritide 10 years ago, interest in new vasodilators has grown. Therapies that improve not only hemodynamics and symptoms but also long-term outcomes are in high demand, and numerous new vasodilatory agents have been investigated, including various natriuretic peptides, soluble guanylyl cyclase agents, renin-angiotensin-aldosterone system-modifying agents, and others. A review of the literature shows that few of them rise to the challenge set by NTG and SNP.
AB - Despite substantial improvements in treatment for chronic heart failure, morbidity and mortality for acute decompensated heart failure (ADHF) remain high. Treatment of ADHF is focused on controlling symptoms rather than improving long-term outcomes. The vasodilators nitroglycerin (NTG) and sodium nitroprusside (SNP) have been used in ADHF for decades, but, since the development of nesiritide 10 years ago, interest in new vasodilators has grown. Therapies that improve not only hemodynamics and symptoms but also long-term outcomes are in high demand, and numerous new vasodilatory agents have been investigated, including various natriuretic peptides, soluble guanylyl cyclase agents, renin-angiotensin-aldosterone system-modifying agents, and others. A review of the literature shows that few of them rise to the challenge set by NTG and SNP.
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U2 - 10.1016/j.cardfail.2013.05.007
DO - 10.1016/j.cardfail.2013.05.007
M3 - Review article
C2 - 23834924
AN - SCOPUS:84893870053
SN - 1071-9164
VL - 19
SP - 478
EP - 493
JO - Journal of cardiac failure
JF - Journal of cardiac failure
IS - 7
ER -